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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ethinyl Estradiol
supplement:
Glutathione
Research Papers that Mention the Interaction
“LC-MS/MS analysis revealed two GSH conjugate isomers with MH+ ions at m/z 620, which were formed by reaction between GSH and EE with the oxygen being added to either the internal or terminal carbon of the ethynyl moiety.”
Formation of Both Heme and Apoprotein Adducts Contributes to the Mechanism-Based Inactivation of Human CYP2J2 by 17α-Ethynylestradiol“Conclusively, 17α-estradiol may have a long-term negative effect on the endogenous glutathione level through its ability to down-regulate the glutathione synthesis during serum deprivation.”
17α-Estradiol down-regulates glutathione synthesis in serum deprived PC-12 cells“Biochemical analyses indicated that EE significantly increased both the levels of glutathione (reduced [GSH] and oxidized [GSSG] forms) per mg protein in mitochondria and nuclei, while the percentage of total glutathione in the oxidized form was not affected.”
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