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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Ethinyl Estradiol and Glutathione

Research Papers that Mention the Interaction

LC-MS/MS analysis revealed two GSH conjugate isomers with MH+ ions at m/z 620, which were formed by reaction between GSH and EE with the oxygen being added to either the internal or terminal carbon of the ethynyl moiety.
Drug Metabolism and Disposition  •  2018  |  View Paper
Biochemical analyses indicated that EE significantly increased both the levels of glutathione (reduced [GSH] and oxidized [GSSG] forms) per mg protein in mitochondria and nuclei, while the percentage of total glutathione in the oxidized form was not affected.
Toxicological sciences : an official journal of the Society of Toxicology  •  2003  |  View Paper
Ethinyloestradiol administration induced a significant decrease in plasma and renal GSH and the tripeptide was almost absent from bile.
Pharmacology & toxicology  •  2002  |  View Paper
Biliary glutathione secretion was diminished without modification of liver and blood glutathione concentration or redox status following single EE dose whereas, after 5 days of EE treatment, a significant increase in liver glutathione was observed, suggesting that EE may interfere with the glutathione secretory process.
Toxicology letters  •  1994  |  View Paper