Possible Interaction: Ethanol and Zonisamide

“Conclusion: These results indicate that a single dose of zonisamide reduces urge to drink and the quantity of ethanol self-administered by risky drinkers during their second hour of access to alcohol.”

“Scientific Significance: Zonisamide may help individuals drinking at risky levels reduce their intake of alcohol.”

“Co-administration of zonisamide and ethanol caused a reduction of ethanol-induced alterations.”

“In our previous study, we determined that zonisamide decreases changes in hippocampal bioelectric activity induced by a single dose of ethanol.”

“Combined administration of ethanol and zonisamide (60 mg/kg) resulted in a markedly synergistic effect in the examined structures.”

“Some elements of the … mechanism of action that zonisamide has in common with ethanol , give rise to the question of whether there is an interaction between these two agents and whether there is any risk associated with the enhanced depressive effect of these agents on the central nervous system.”

“The administration of a 50 mg/kg (IP) dose of zonisamide to mice resulted in a marked lowering in ethanol consumption.”

“These results provide evidence that zonisamide administration will decrease ethanol consumption by both mice and rats in limited access models of drinking, and might, like topiramate, be useful as a medication for alcoholism.”

“Seizures in mice treated with ethanol for 1–3 weeks were decreased by ZNS at a dose of 75 mg kg−1, i.p.,”