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Last Updated: 3 years ago

Possible Interaction: Ethanol and Zolpidem



Research Papers that Mention the Interaction

The study was designed to test whether the effects of zolpidem and alcohol are simply additive or reflect potentiation.
The Journal of clinical psychiatry  •  1995  |  View Paper
Moreover, … and alcohol were shown to significantly affect expression of these subunits … brain regions, dosage and duration of treatment with zolpidem as well as age, gender and additional consumption of alcohol, a history of abuse … might play a role in the development of tolerance and dependence in individual patients.
Fortschritte der Neurologie-Psychiatrie  •  2001  |  View Paper
When zolpidem is ingested with other medications or ethanol , admission to the ICU was common in our series.
American journal of therapeutics  •  2011  |  View Paper
On the other hand, in combined intoxications with other CNS active drugs or ethanol a zolpidem dose as low as 0.1-0.15 s induced coma in some patients, even if the amount of the additionally ingested drugs in itself would not have caused a comatose state.
Schweizerische medizinische Wochenschrift  •  1996  |  View Paper
Because of the current highly prevalent co-abuse of ethanol and benzodiazepine drugs in humans, the use of zolpidem and other α1GABAA receptor ligands during ethanol withdrawal should be monitored carefully.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas  •  2020  |  View Paper
Ethanol reduced mPSC amplitude, frequency, and decay kinetics, while attenuating or exaggerating allosteric actions of zolpidem and allopregnanolone, respectively.
Brain Research  •  2013  |  View Paper
ethanol (0.32 and 1 g/… administered alone, showed interactions with zolpidem (10 and 30 mg/kg) leading to reduced rotarod performance and grip strength; in contrast, combination of ethanol (0.…/kg) with almorexant (100 and 300 mg/kg) did not reduce performance or grip strength below ethanol alone.
Neuropsychopharmacology  •  2011  |  View Paper
Ethanol exposure for 4 h decreased biotinylated surface expression of GABAA receptor α1 subunits and reduced zolpidem (100 nM) enhancement of GABA-evoked currents.
Molecular Pharmacology  •  2010  |  View Paper
Ethanol intake (grams/kg/day) by wild‐type mice decreased significantly after diazepam or zolpidem but increased after L‐655,708 administration.
Synapse  •  2006  |  View Paper
Since zolpidem potentiation exhibited a substantial age-dependent increase in untreated neurons, this finding supported the idea that ethanol arrests synaptic development.
The decay phase of mPSCs showed concentration-dependent potentiation by zolpidem (0.03-100 microM), which was substantially blunted after ethanol exposure.
Brain Research  •  2006  |  View Paper
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