Possible Interaction: Ethanol and Zimeldine

“Our previous studies showed that zimeldine decreased ethanol intake in rats and nondepressed alcohol abusers.”

“The higher dose of ethanol increased plasma zimelidine and norzimelidine concentrations.”

“ Zimelidine , a relatively specific 5-hydroxytryptamine reuptake blocker, attenuates the impairing effects of ethanol on learning and memory.”

“The results are discussed in relation to recent literature where ethanol preference has been found to be attenuated by zimelidine.”

“Similarly, studies of alcohol-dependent human subjects have shown that treatment with 5-HT reuptake inhibitors (i.e. zimeldine , citalopram, fluoxetine, and fluvoxamine) decreases the desire to drink alcohol and improves symptoms of alcohol-related anxiety and depression in patients who have undergone detoxification.”

“Similarly, studies of alcohol-dependent human subjects have shown that treatment with 5-HT reuptake inhibitors (i.e. zimeldine , citalopram, fluoxetine, and fluvoxamine) decreases the desire to drink alcohol and improves symptoms of alcohol-related anxiety and depression in patients who have undergone detoxification.”

“Previous research demonstrated that serotonin uptake blockers (e.g., zimeldine , sertraline, fluoxetine) reduce voluntary ethanol consumption in rats and humans.”

“Our data suggest that zimelidine modifies alcohol intake by a different mechanism than previously tested drugs, possibly by modulating the central neural mechanism that controls drinking of alcohol.”

“ Zimeldine slightly improved performance in the Continuous Performance Task and antagonized effects of alcohol in both tasks.”

“Clinically established antidepressants which enhanced ethanol sedation only at doses considerably above therapeutic levels were zimelidine and iprindole.”