Possible Interaction: Ethanol and Yohimbine

“In addition, these results indicate that ethanol and yohimbine may act additively to increase ethanol intoxication and that they may increase NE turnover through different physiological mechanisms.”

“The combined administration of ethanol and yohimbine had a clear additive effect of increasing the severity of acute intoxication compared with ethanol or yohimbine alone, and resulted in a significantly greater plasma MHPG response compared with either drug given alone.”

“Also, MCPP but not yohimbine or placebo significantly increased craving for alcohol.”

“ Yohimbine (0.625 and 1.25 mg/kg) increased ethanol self-administration, and the latter dose also decreased latency to complete the response requirement.”

“ Yohimbine elicited reinstatement of ethanol seeking in both lines.”

“Hexamethonium had no effect, whereas yohimbine by itself reduced ethanol absorption, but no additional effects were observed with presence of high acetaldehyde.”

“The alpha-2 adrenoceptor antagonist yohimbine (1 mg/kg), or a mixed antagonist of imidazoline and alpha-2 adrenoceptors, idazoxan (60 micrograms/kg), counteracted the synergistic interaction between ethanol and clonidine on LORR; yohimbine was more effective than idazoxan, but the difference was not significant.”

“Simultaneous treatment with yohimbine attenuated the clonidine-induced reduction in ethanol intake.”

“The increase in ouabain binding and K+-phosphatase activity associated with (Na+,K+)-ATPase in rats treated with repeated yohimbine injections was prevented by chronic ethanol.”

“The effects of yohimbine treatment were eliminated or reduced in rats also treated with ethanol.”

“ Ethanol inhibited the [3H]yohimbine binding with an IC50 of 200 mM. This inhibition was "competitive-like" as increasing concentrations of ethanol resulted in an increased KD, but not a decrease in Bmax.”

“Similar effects were produced by norepinephrine and these, as well as those of ethanol , were significantly reduced by yohimbine.”