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Last Updated: 3 years ago

Possible Interaction: Ethanol and Vorinostat

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supplement:

Ethanol

drug:

Vorinostat

Research Papers that Mention the Interaction

“Recent work in rodents has shown that systemic administration of pan HDAC class I and II inhibitors, TSA and N-hydroxy-N-phenyl-octanediamide [SuberoylAnilide Hydroxamic Acid] (SAHA), and of the more selective inhibitor (mainly HDAC1 and HDAC9) MS-275, decrease binge-like alcohol drinking in mice.”

“ SAHA selectively reduced ethanol operant self-administration and seeking in rats.”

[Epigenetic mechanisms and alcohol use disorders: a potential therapeutic target].

Biologie aujourd'hui • 2017 | View Paper

“We further report that systemic administration of the FDA-approved HDAC inhibitor, SAHA , inhibits the motivation of rats to seek alcohol.”

Chromatin remodeling — a novel strategy to control excessive alcohol drinking

Translational Psychiatry • 2013 | View Paper

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