Possible Interaction: Ethanol and Vitamin K

“Our results showed that VK2 acted synergistically with ethanol (EtOH) to inhibit the viability of Smmc-7721 cells, mainly because cytochrome P450 2E1 (CYP2E1) was activated by EtOH.”

“The synergistic effect of VK2 and EtOH was also observed in QGY-7703 cells, which also express CYP2E1.”

“ Menadione , a good quinone reductase substrate, increased the elimination rate of orally administered ethanol thereby decreasing its bioavailability (as measured by the area under the curve (AUC) relating blood level to time) and its induced hepatic triglyceride accumulation.”

“These data indicate that ethanol potentiates oxygen uptake and toxicity due to menadione bisulfite most likely by generation of NADH for redox cycling of this model quinone.”

“As a consequence, the effect of these agents on the microsomal oxidation of ethanol was complex since it appeared that paraquat and menadione stimulated the oxidation of ethanol by a .OH-dependent mechanism, but inhibited the oxidation of ethanol by a cytochrome P-450-dependent oxidation pathway.”

“Methylene blue, phenazine methosulphate and menadione stimulated both ethanol oxidation and respiration, irrespective of the prior treatment of the donor animal.”

“Among them, ethanol production showed resistance to the cytotoxicity of menadione , suggesting the resistance of glycolysis to menadione.”

“Following the addition of 70 mass % ethanol , the solubility of VK3 increased by as much as 170-fold, resulting in an increased rate of VK3 release.”

“ Menadione quenched twofold the fluorescence of Chl a and BChl a in pea chloroplasts, chromatophores of purple bacteria, and … at concentrations of 50‐80 μM. To obtain twofold quenching in Triton X‐100 micelles and in ethanol , the addition of 1.3 mM … 11 mM menadione was required, respectively.”