Possible Interaction: Ethanol and Vitamin D

“The area under the ethanol concentration time curve (0----180 min) increased after CC treatment implying a change in clearance.”

“A smaller volume of distribution of ethanol was evident after pretreatment with CC ; 0.636 L/kg compared with 0.675 L/kg after placebo.”

“The rate of elimination of ethanol from blood was about 5% slower in subjects given the CC tablet.”

“The speed of absorption of alcohol was faster in subjects treated with CC.”

“ Chronic ethanol consumption is an etiological factor for breast cancer that affects vitamin D metabolism; however, the mechanisms underlying this causal association have not been fully clarified.”

“Coadministration of ethanol and 25-hydroxyvitamin D3 reduced in 60% renal 25-hydroxyvitamin D3-dependent Cyp24a1 upregulation (P<0.05).”

“ Ethanol almost completely attenuated the pro‐depressive effect of CMS (assessed with the tail suspension test) in both the CC and CT genotypes in the HA line.”

“BACKGROUND Excessive intake of alcohol is often associated with low or subnormal levels of vitamin D even in the absence of active liver disease.”

“A repeated open application test with isopropyl lauroyl sarcosinate 5% ethanol also resulted in erythema on D3.”

“ Ethanol has been found to affect pulmonary cells by interfering with vitamin D metabolism and pulmonary defense mechanisms.”

“Multiple linear regression analysis also showed that statin use (b = 2.2; p = 0.004) and no alcohol use (b = -1.8; p = 0.03) significantly increased 25(OH)D levels.”

“When vitamin D concentrations were grouped into sunny season (Summer + Fall) compared to not sunny season (Winter + Spring), there was a significant ethanol by season interaction (p = 0.0028), with alcohol-drinking women having lower circulating vitamin D compared to low/unexposed women in seasons of low sun availability.”

“rs7679673 CC in individuals that consumed alcohol had an OR of 4.37 (p = 0.041).”