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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Ascorbic acid pretreatment resulted in significant enhancement in blood ethanol clearance and an increase in serum triglyceride levels after ethanol consumption in half of the subjects.”
Effect of ascorbic acid on the consequences of acute alcohol consumption in humans“The antioxidants N-acetyl cysteine and vitamin C lowered the alcohol elevation of ROS and blunted the alcohol induction of CYP2A5, but not CYP2E1, suggesting ROS play a novel role in the crosstalk between CYP2E1 and CYP2A5.”
“In the acute study, the postinfusion rate of ethanol decline in the blood of animals treated with ascorbic acid was significantly higher when compared with animals treated with fructose, and the rate in the two treated groups was significantly higher than in untreated controls.”
“Our results showed that 100 mM ethanol significantly induced CYP2A6 mRNA and protein (∼150%) and increased ROS formation, and induction of gene expression and ROS were both completely blocked by treatment with either a CYP2E1 inhibitor (diallyl sulfide) or an antioxidant ( vitamin C).”
“At both dosages of alcohol , short-term as well as long-term pretreatment with ascorbic acid significantly enhanced the clearance of plasma alcohol.”
“In five of six patients, pretreatment with oral ascorbic acid resulted in a blunting, but not statistically significant, effect on maximum blood NDMA levels after consumption of ethanol.”
“The loss of vitamin A is eliminated completely if ascorbic acid (0.1% w/v) is added to the ethanol before it is used in the preassay extraction.”
“After the ingestion of 2.0 g ascorbic acid and breakfast, plasma ascorbic acid rose from a fasting concentration of … 0900 h. to a peak of 26.9 +/- m 2.0 ng/ml at 1500 h. When 35 g ethanol … ascorbic acid and breakfast, plasma ascorbic … least 24 h.”
“Further studies have demonstrated that the rate of clearance of ethanol from the blood is associated with increased levels of leucocyte ascorbic acid.”
“ Vitamin C and 4-methylpyrazole prevented the increase on O2- generation induced by ethanol in cultured MAB vascular smooth muscle cells.”
Acute Ethanol Intake Induces NAD(P)H Oxidase Activation and Rhoa Translocation in Resistance Arteries
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