Possible Interaction: Ethanol and Vitamin B 6

“The value of pyridoxine or its congener metadoxine as an agent for hastening ethanol metabolism or improving vigilance in acute alcohol intoxication is controversial.”

“In conclusion: I) acute high doses of alcohol in dogs lower plasma PLP accumulation from precursor pyridoxine , 2) this effect can not be accounted for by increased PLP removal from plasma, 3) these composite data indirectly suggest an alcohol-induced abnormality in plasma PLP formation.”

“ Ethanol also diminished the rate of release of pyridoxal phosphate into the perfusate by the livers of vitamin B6-deficient rats.”

“In isolated perfused livers, the addition of 18 mM ethanol lowered the pyridoxal phosphate content of livers from vitamin B6-sufficient animals and deceased the net synthesis of pyridoxal phosphate from pyridoxine by the livers of vitamin B6-deficient animals.”

“Thus the derangement of pyridoxal phosphate metabolism produced by ethanol is dependt upon its oxidation.”

“Sideroblastic anaemia caused by interference of alcohol with the metabolism of pyridoxine is common and so is haemolytic anaemia caused by hypersplenism and megaloblastic anaemia.”

“ Alcohol , 400-250 mg/dl over 2.5 h, inhibited the transport of pyridoxal from the maternal to fetal compartments by approximately 42% (P = 0.03) and resulted in a lower transfer of pyridoxal 5'-phosphate into the fetal perfusate (P = 0.02).”

“There is a great deal of interest in the adverse effects of alcohol on pyridoxine (vitamin B6) and folic acid metabolism.”

“ Chronic ethanol exposure reduced Y-type electric maze scores and the protein/mRNA expression levels of MBP and PLP in the prefrontal cortex and hippocampus, and these effects were reversed by quetiapine treatment.”

“Furthermore, the key cofactor of transsulfuration, pyridoxal-5'-phosphate , significantly declined in the plasma after a week of the ethanol intervention, whereas an increase was observed in brain tissue.”

“Intramuscular administration of 187.2 mg/kg of pyridoxine displaced the ethanol-lethality dose curve significantly toward the right (p < 0.005) and increased the LD50 of ethanol from 4.46 to 5.19 g/kg (p < 0.005).”

“In B6 deficiency, ethanol feeding reduced maternal liver PLP by 22%.”