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Last Updated: 3 years ago

Possible Interaction: Ethanol and Verapamil



Research Papers that Mention the Interaction

The Ca2+ channel blockers verapamil and nifedipine were chosen because preclinical research has shown them to decrease certain behavioral effects of ethanol in animals.
Alcoholism, clinical and experimental research  •  1992  |  View Paper
Compared with placebo, verapamil increased the peak blood ethanol concentration (106.45 ± 21.40 to 124.24 ± 24.74 mg/dl, p < 0.05) and area under the ethanol concentration versus time curve (365.67 ± 93.52 to 475.07 ± 97.24 mg · hr/dl, p < 0.005).
The findings of our study suggest that verapamil significantly inhibits ethanol elimination, resulting in elevated blood ethanol concentrations that prolong the intoxicating effects of alcohol.
Clinical pharmacology and therapeutics  •  1992  |  View Paper
Verapamil prevents the development of tolerance to hypnotic action of ethanol , whereas cinnarizine prevents the development of tolerance to the hypnotic and hypothermic action of ethanol.
Alcohol and alcoholism  •  1993  |  View Paper
Inhalation exposure to ethanol reduces the AUC of both verapamil (approximately 2.7 fold) and norverapamil enantiomers (>2.5 fold), reduces the AUC(0-∞) of (+)-(S)-IBU (approximately 2 fold) and inhibits preferentially the metabolism of (-)-(R)-FLU.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2015  |  View Paper
Verapamil could abolish the inotropic effect of ethanol as well as that of butanol and EtOAc extracts.
Pharmaceutical biology  •  2010  |  View Paper
Although lidocaine (50 and 100 μmol/L), a local anesthetic agent, and hexamethonium (… 500 μmol/L), a ganglionic blocking agent, failed to affect these contractions, verapamil (1–50 μmol/L) and nifedipine (1–50 μmol/L), selective … of L-type Ca2+ channels, significantly inhibited the contractile responses of ethanol.
Acta Pharmacologica Sinica  •  2009  |  View Paper
This effect was significant when verapamil at 10 or 20 mg/kg was given 1 hr before ethanol.
Digestive Diseases and Sciences  •  2005  |  View Paper
In a previous paper we reported that another calcium channel antagonist, verapamil , worsened the toxic effects of ethanol on rat myocardium.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie  •  1998  |  View Paper
Furthermore, ethanol significantly augmented the contraction induced by phenylephrine in the presence of verapamil , and did not have any effects on the contractions induced by A23187, Ba2+, PDBu and BAY K 8644.
Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence  •  1997  |  View Paper
We further report that BAPTA‐AM and verapamil also have a neuroprotective effect on normal neurons exposed to high concentrations of ethanol.
Journal of neuroscience research  •  1997  |  View Paper
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