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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The Ca2+ channel blockers verapamil and nifedipine were chosen because preclinical research has shown them to decrease certain behavioral effects of ethanol in animals.”
Interaction between ethanol and calcium channel blockers in humans.“Compared with placebo, verapamil increased the peak blood ethanol concentration (106.45 ± 21.40 to 124.24 ± 24.74 mg/dl, p < 0.05) and area under the ethanol concentration versus time curve (365.67 ± 93.52 to 475.07 ± 97.24 mg · hr/dl, p < 0.005).”
“The findings of our study suggest that verapamil significantly inhibits ethanol elimination, resulting in elevated blood ethanol concentrations that prolong the intoxicating effects of alcohol.”
“ Verapamil prevents the development of tolerance to hypnotic action of ethanol , whereas cinnarizine prevents the development of tolerance to the hypnotic and hypothermic action of ethanol.”
“Inhalation exposure to ethanol reduces the AUC of both verapamil (approximately 2.7 fold) and norverapamil enantiomers (>2.5 fold), reduces the AUC(0-∞) of (+)-(S)-IBU (approximately 2 fold) and inhibits preferentially the metabolism of (-)-(R)-FLU.”
Impact of inhalational exposure to ethanol fuel on the pharmacokinetics of verapamil, ibuprofen and fluoxetine as in vivo probe drugs for CYP3A, CYP2C and CYP2D in rats.“ Verapamil could abolish the inotropic effect of ethanol as well as that of butanol and EtOAc extracts.”
“Although lidocaine (50 and 100 μmol/L), a local anesthetic agent, and hexamethonium (… 500 μmol/L), a ganglionic blocking agent, failed to affect these contractions, verapamil (1–50 μmol/L) and nifedipine (1–50 μmol/L), selective … of L-type Ca2+ channels, significantly inhibited the contractile responses of ethanol.”
“This effect was significant when verapamil at 10 or 20 mg/kg was given 1 hr before ethanol.”
“In a previous paper we reported that another calcium channel antagonist, verapamil , worsened the toxic effects of ethanol on rat myocardium.”
“Furthermore, ethanol significantly augmented the contraction induced by phenylephrine in the presence of verapamil , and did not have any effects on the contractions induced by A23187, Ba2+, PDBu and BAY K 8644.”
“We further report that BAPTA‐AM and verapamil also have a neuroprotective effect on normal neurons exposed to high concentrations of ethanol.”
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