Possible Interaction: Ethanol and Vasodilator Agents

“Thus, alcohol influences thermoregulation so that body core temperature is lowered not only by automatic mechanisms (sweating and skin vasodilation ) but also behaviorally.”

“4) Ethanol affects vascular endothelial functions, inhibiting endothelial NO- and EDHF-dependent vasorelaxations.”

“ Chronic ethanol increases the reactivity of intact microvessels to vasoconstrictors and results in decreased reactivity to vasodilators.”

“Although alcohol and other substances, such as caffeine, cause local vasodilation that can exacerbate the symptoms, the cause has yet to be elucidated.”

“In the individual subjects there was a close negative correlation (r = -0.90-0.94) between the ethanol exchange ratios and the corresponding adipose tissue blood flow values, as measured by 133Xe clearance, in response to local vasodilation.”

“IS a vasodilator and prevents gastric injury from ethanol.”

“Pretreatment with alcohol caused pial vasodilation (14.0%), and, after inhalation of cigarette smoke, the pial vasodilation occurred earlier (peak at t = 1-5 min; 30.2%) and was larger, without an initial vasoconstriction.”

“The ability of ethanol to augment the release of the platelet inhibitor and vasodilator nitric oxide may, in part, contribute to the beneficial cardiovascular effects associated with moderate alcohol consumption.”

“Recent studies suggest that the neurotransmitter which mediates relaxation induced in … oxide (NO) or by a substance which releases NO.l.2 Ethanol … vasodilators whose action is mediated by the release of NO.3 This study was … and chronic ethanol administration on NANC-induced relaxation of the rat ANO.”

“These results suggest that ethanol produces vasoconstriction in the spinal cord that is countered by autoregulatory vasodilation at low blood pressures.”