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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Valproic Acid
Research Papers that Mention the Interaction
“The results suggest that DPA may be a useful agent in the control of the hyperexcitable state induced by ethanol withdrawal and that the GABA system may be involved in this state.”
The modification of the ethanol withdrawal syndrome in rats by Di-n-propylacetate“Toxicological results led the pathologist to rule that death was due to an intoxication caused by the simultaneous ingestion of high VPA concentrations and alcohol , with a suicidal legal-medical etiology.”
“We describe two case reports involving valproic acid intoxication with ingestion of ethanol.”
“ VPA treatment increased levels of glycolytic intermediates, increased expression of glycolysis genes, and increased ethanol production.”
Valproate inhibits mitochondrial bioenergetics and increases glycolysis in Saccharomyces cerevisiae“Concomitant injection of VPA (5 min before ethanol) and ethanol had significantly stronger anticonvulsant effects than VPA alone (p < 0.001).”
“The obtained results show that short-term ethanol administration has anticonvulsant effects along with VPA, and enhances the anticonvulsant effects of VPA.”
“Low doses of 8-OH DPAT enhanced ethanol intake even when food and water were offered as alternatives.”
“Therefore 8-OH DPAT may both increase or decrease ethanol consumption in the rat depending on the dose used.”
“In co-medication with valproate and carbamazepine, ethanol significantly increased the anticonvulsant effectiveness of both antiepileptic drugs.”
“Subchronic premedication of ethanol did not reveal marked decrease of its additive anticonvulsant action and only tended to reduce the effectiveness of valproate and carbamazepine.”
“Incubation with valproic acid plus allyl alcohol induced an irreversible depletion of hepatocellular glutathione, in contrast to allyl alcohol alone which induced a transient loss.”
“However, this dose of VAL enhanced the intoxicating effects of ethanol (2.0g/kg).”
“Similarly, 5 days of oral dosing with VAL (400 and 600 mg/kg) reliably reduced the intake of ethanol without affecting the intake of water.”
“produced a mild conditioned taste aversion to a saccharin solution, suggesting that VAL may reduce intake of ethanol because it produces a general malaise.”
“The putative D3 agonist 7-OH DPAT produced a decrease in ethanol intake in the first h to 45-55% of control levels for the P rat (p < 0.01) and to 25-70% of control values in the HAD line (p < 0.001).”
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