Possible Interaction: Ethanol and Valine

“We conclude that both short- and long-term ingestion of ethanol inhibit the placental uptake and maternal-fetal transfer of an essential amino acid-- valine.”

“Under basal conditions, ethanol induced dose-dependent changes in the rates of incorporation of tritiated thymidine, uridine, and valine.”

“ Ethanol lowered the concentration of most plasma amino acids (AA) or related compounds in stressed rats (e.g., aspartic acid, threonine, serine, glycine, alanine, valine , tyrosine, phenylalanine, tryptophan).”

“Addition of the alcohol into incubation media caused the ethanol-dependent inhibition of sRNA aminoacylation by valine.”

“This inhibitory action of ethanol on valine incorporation was reversed by increasing exogenous glucose concentrations.”

“Incorporation of valine into plasma proteins was reduced in the ethanol group compared to the sucrose group, but not compared to the lipid control group, again demonstrating no ethanol-specific effect.”

“… ethanol caused a 32% … incorporation of labelled valine into liver protein compared to the sucrose group during the 20 min interval, no such reduction was found when the synthetic … liver protein was calculated (182 vs. 214 (not significant) pmol X mg protein-1 X min-1) for same interval.”

“Similar inhibitions by ethanol were also observed when leucine or valine were used as a label for either total export proteins or albumin.”

“ Ethanol inhibited incorporation of labelled valine into stationary and medium proteins of parenchymal cells.”

“Ingestion of ethanol inhibits placental uptake and transfer of valine to the rat fetus and may be contributory to the impaired fetal growth and dysgenesis associated with the fetal alcohol syndrome.”