Possible Interaction: Ethanol and Uridine Triacetate

“Epidemiological studies have reported a reduction in the prevalence of Alzheimer’s disease in individuals who drink low amounts of alcohol; low or moderate concentrations of ethanol protect against β-amyloid (Aβ) toxicity in hippocampal neurons; and excessive amounts of ethanol increase accumulation of Aβ and Tau phosphorylation.”

“During tau induction, ethanol exposure (1.25-5mg/ml) dose-dependently increased tau protein levels and reduced cell viability.”

“ Ethanol delayed tau clearance suggesting ethanol impedes its degradation.”

“RESULTS Chronic et anol fe eding led to significant (P < 0.05) decreases in M-mode Fractional Shortening, ejection fraction, and the cardiac output index as well as increases in Tau . ”

“Furthermore, high concentration ethanol (300 mM) significantly decreased the rise in tau and tau decay value of P1, whereas low concentration ethanol (2-5mM) significantly increased these values of P1.”

“In the presence of ethanol , the mean half-width, area under curve, rise Tau and decay Tau of P1 were significantly decreased.”

“We found that ethanol increased phosphorylated tau recognized by the paired helical filament (PHF)-1 antibody and by the antibody against tau phosphorylated at Ser199.”

“ Ethanol , and acetonitrile being 2-fold more effective, markedly increased both tau exch and Ea in bovine RBC as compared to the well-known mercurial inhibitor of water channels, p-chloromercuribenzene sulfonate.”