Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Ethanol and Urea





Research Papers that Mention the Interaction

Following co-administration of ethanol and an inhibitor of acetaldehyde metabolism, such as disulfiram or calcium carbamide , acetaldehyde blood concentrations may increase 5-10 fold over normal level (reviewed in [1]).
Report on carcinogens : carcinogen profiles  •  1985  |  View Paper
Under ethanol an increase of several amino acids and urea levels were observed.
Beitrage zur gerichtlichen Medizin  •  1992  |  View Paper
Administration of 20% ethanol (5 g/kg b.wt/day) for 60 days resulted in a significant rise in the plasma concentrations of urea and creatinine with decreased levels of uric acid.
Toxicology mechanisms and methods  •  2020  |  View Paper
It was demonstrated that ethanol inhibits State 3 and uncoupled mitochondrial respirations, decreases the accessibility of mitochondrial adenylate kinase localized in the intermembrane space of mitochondria, and suppresses ureagenic respiration and synthesis of urea in cultured hepatocytes.
Biofizika  •  2010  |  View Paper
The unidirectional fluxes of urea and sodium were increased slightly in 3% (v/v) ethanol and markedly in 20% (v/v) ethanol, but those of chloride only increased in 20% ethanol.
The American Journal of Digestive Diseases  •  2005  |  View Paper
In sham rats urea N appearance was also increased (+39%) following ethanol administration in comparison to sham-operated rats without alcohol, albeit to a lesser degree.
Subsequently, the urea N appearance was enhanced (+60%) in uremic rats with alcohol as compared to uremic animals without alcohol.
Nephron  •  1989  |  View Paper
2) The dose-dependent effects of ethanol upon the hepatic level of urea are also shown.
A significant decrease by 20 per cent in the liver content of urea is only observed 60 min after the administration of the 50 mmoles/kg ethanol dose. (
Biochemical pharmacology  •  1979  |  View Paper
Addition of ethanol had little effect on either proline uptake or oxygen consumption, but strongly inhibited the production of both urea and glucose and caused further accumulation of glutamate and lactate.
The Biochemical journal  •  1978  |  View Paper
The presence of urea decreases the hydrophobic effect of a monovalent alcohol , strongly at low temperatures, to a lesser degree at high temperatures (60 degrees C).
International journal of peptide and protein research  •  1976  |  View Paper
Ethanol extract at 400 mg/kg decreased the … ± 0.09; P<0.001) and urea (32.86 ± 5.88; P<0.001) associated with a significant increase in body weight (7.16 ± … urine volume output (11.95 ± 0.79; P<0.05) as compared to the toxic control group.
Indian journal of pharmacology  •  2011  |  View Paper
Show More