Possible Interaction: Ethanol and Ubiquinone

“Moreover, two different female patients (cases 2 and 10) who once had palpitations when they consumed alcohol noticed the disappearance of the symptom after taking coenzyme Q10 , which has a therapeutic effect on mitochondrial abnormality (3).”

“Conclusion: CoQ10 rescues apoptotic response through caspase-2 inhibition toward EtOH treatment.”

“ Ethanol , either separately or in combination with lovastatin, diminished liver stores of CoQ10 by almost 40%.”

“… ethanol … quinone derivatives 2,3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone (ubidecarenone, coenzyme Q10), 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-… to ethanol load, at a dose of 10, 11.5 and 30 mg/kg of body weight, respectively.”

“In vivo modulation of ubiquinone with ethanol and in vitro pentane extraction show that ubiquinone is not required either for NADH‐ferricyanide reductase, acetaldehyde dehydrogenase activity, or Ca2+ and Mg2+ stimulated ATPases.”

“ CoQ10 could antagonize the apoptosis inducing effect of EtOH.”

“In EtOH-exposed corneal fibroblasts, CoQ10 pretreatment significantly reduced mitochondrial depolarization and ROS production at 30, 60, 90, and 120 min and inhibited the activation and expression of caspases 2 and 3 at 2 h after EtOH exposure.”

“The inhibition of cell apoptosis by CoQ10 was significant at 8 and 12 h after EtOH exposure.”

“These findings support the proposition that CoQ10 plays an antiapoptotic role in corneal fibroblasts after ethanol exposure.”