Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Ethanol and Tryptophan





Research Papers that Mention the Interaction

Lowered tryptophan levels and ingestion of alcohol were associated with increased aggression.
Psychopharmacology  •  2005  |  View Paper
Two important findings have been made recently: (1) subsets of individuals (e.g., persons self-rating high on aggressive or hostility scales) may differ in their susceptibility to aggression produced through plasma tryptophan depletion; and (2) alcohol in combination with L-tryptophan depletion has an additive effect on aggression.
Advances in experimental medicine and biology  •  1999  |  View Paper
Alcohol has been found to mimic the effects of tryptophan or serotonin.
Medical anthropology  •  1995  |  View Paper
Alcohol (ethanol) exerts a variety of effects on tryptophan (Trp) and 5-hydroxytryptamine (5-HT, serotonin) metabolism in man and experimental animals.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement  •  1993  |  View Paper
Levels of tryptophan in brain are increased by the action of chronic ethanol , particularly in the event of compromised hepatic function.
Medical hypotheses  •  1991  |  View Paper
Single administration of ethanol in doses of 3 and 5 g/kg per os caused a 4--5fold increase in plasma 11-hydroxycorticosteroids after one hour and an approximately 2 fold increase in liver tryptophan pyrrolase activity after 5 hours.
Farmakologiia i toksikologiia  •  1981  |  View Paper
We therefore tested whether dietary tryptophan TRP ) enhancement would modulate stress-induced desire for alcohol and whether it would affect the two populations (BD/NBD) differently.
Behavioural pharmacology  •  2014  |  View Paper
AIMS We have previously suggested that acute ethanol consumption by normal subjects decreases the availability of circulating tryptophan (Trp) to the brain by activating liver Trp pyrrolase, the first and rate-limiting enzyme of the (major) kynurenine pathway of Trp degradation.
Alcohol and alcoholism  •  2009  |  View Paper
They argue that this occurs because chronic ethanol intake inhibits synthesis of hepatic tryptophan oxygenase (TPO), the major quantitative catabolic enzyme for Trp metabolism (Young et al. 1978).
Biological Psychiatry  •  1988  |  View Paper
High pressures (120 and 240 MPa) and added ethanol resulted in change in casein hydrophobicity by exposure of tryptophan residues , as confirmed by spectroscopic methods.
Food chemistry  •  2019  |  View Paper
Show More