Possible Interaction: Ethanol and Tropisetron

“Conversely, the 5-HT3/4 antagonist tropisetron has been shown to decrease ethanol intake and morphine-induced increases in mesolimbic DA levels.”

“The ability of a selective 5-hydroxytryptamine (5-HT(3)) … antagonist, ICS 205-930 (3-tropanyl-indole-1-carboxylate, tropisetron ), to block the … stimulus effects of ethanol was investigated in rats that were trained to discriminate ethanol (1.25 g/kg ip) from saline with food as the reinforcement.”

“The effect of 2.0 g/kg of EtOH was reduced by ON (0.1 mg/kg and 1.0 mg/kg sc) and, to the lesser extent and only in limited dose range (0.01 mg/kg) by TR.”

“ Tropisetron (but not ON) increased concentrations of EtOH in the blood.”

“ Tropisetron (1 and 10 ng) decreased ethanol intake during the first hour of access.”

“ Tropisetron , when injected bilaterally into the NAS, significantly reduced EtOH intake in EtOH high-preferring animals.”

“Both 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; the agonist of serotonin 5-HT1A receptors) and tropisetron (ICS 205-930, the antagonist of 5-HT3 receptors) reduced ETOH consumption in high-preferring, sham-lesioned rats.”

“Low doses of tropisetron (0.001-0.01 mg/kg ip) and ondansetron (0.00025 mg/kg ip) reduced ethanol consumption and preference.”