Possible Interaction: Ethanol and Triazolam

“Prior to receiving triazolam , as with all hypnotic agents, patients should be cautioned about the additive effects of other depressant drugs and alcohol , and the possibility of residual effects on performance the morning after ingestion.”

“The findings of the present study … that even a moderate amount of ethanol in combination with … clinical dose of triazolam or temazepam can cause performance impairment that might diminish an individual's ability to respond … to unexpected demands (e.g. smoke alarms or middle-of-the-night child care).”

“Among the participants who reported any sedative-like responses to ethanol, the sedative-like effects of ethanol and triazolam were positively correlated.”

“That is, subjects who exhibited the steepest dose-related effects on measures of subjective sedation after ethanol also exhibited the steepest slopes after triazolam.”

“Thus, triazolam produced response rate slowing at relatively lower doses than ethanol.”

“After ethanol, triazolam total AUC0‐∞. increased (X̄ ± SD = 21% ± 18%).”

“The potential pharmacodynamic interaction of triazolam and ethanol is more important than the minimal pharmacokinetic interaction.”

“Toxic levels may be reached by simultaneous administration of ethanol and triazolam.”

“ Ethanol inhibited metabolism of nifedipine (oxidized nifedipine IC50 3 mg dL−1, where … inhibitor concentration corresponding to a 50% reduction in metabolite formation velocity), triazolam (1‐OH TRZ IC50 1.1 mg dL−1, 4‐OH TRZ …−1) and testosterone (6β‐OH TST IC50 2.4 mg dL−1).”

“Fatal poisoning involving coadministration of alcohol and benzodiazepine, especially triazolam , continues to be a serious problem.”

“Fatal poisoning involving coadministration of alcohol and benzodiazepine, especially triazolam , continues to be a serious problem.”