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Possible Interaction: Ethanol and Tretinoin

supplement:

Ethanol

supplement:

Tretinoin

Research Papers that Mention the Interaction

The perturbation of retinoic acid synthesis by ethanol may underlie the pathogenesis of fetal alcohol syndrome and alcohol-related upper digestive tract cancer.
Chemico-biological interactions  •  2003  |  View Paper
The formation of all-trans retinoic acid tended to be attenuated by 10 mM ethanol.
Alcoholism, clinical and experimental research  •  2001  |  View Paper
In summary, these studies suggest that ethanol may affect the biosynthesis of t-RA in human prenatal hepatic tissues directly and indirectly.
Biochemical pharmacology  •  1999  |  View Paper
All-trans retinoic acid deficiency resulting from ethanol ’s interference with the synthesis of all-trans retinoic acid from retinol was recently suggested to cause the malformations of the fetal alcohol syndrome.
Archives of Toxicology  •  1995  |  View Paper
Combination of RA stimulation with acute in vitro ethanol treatment, however, resulted in significantly lower M theta TGF beta production than TGF beta levels induced by RA alone (p < 0.003).
RA also induced a moderate increase in M theta tumor necrosis factor-alpha (TNF alpha) production, which was down-regulated by ethanol both at the level of secreted and cell-associated TNF alpha.
Alcoholism, clinical and experimental research  •  1994  |  View Paper
To test the hypothesis that ethanol depletes the liver of antitumor promoters such as retinoid , we measured the retinoid concentration in hepatocellular carcinoma tissues and noncancerous surrounding liver tissues in humans known to have a history of alcohol consumption.
Hepatology  •  1991  |  View Paper
Co-treatment with retinoic (0.1 nM) or folic (0.1 mM) acid with the same concentrations of ethanol resulted in significant increases in the remaining hair cells, compared to the ethanol-only treatment group, for every ethanol concentration.
Alcohol  •  2019  |  View Paper
BACKGROUND Maternal alcohol exposure and adult alcohol intake have been shown to perturb the metabolism of various micro- and macro-nutrients, including vitamin A and its derivatives ( retinoids).
Hepatobiliary surgery and nutrition  •  2015  |  View Paper
At the cellular level, ethanol appears to inhibit Sonic hedgehog signalling, alter levels of retionoic acid activity , trigger a Ca(2+)-CamKII-dependent pathway that antagonises WNT signalling, affect cytoskeletal dynamics and increase oxidative stress.
Developmental biology  •  2016  |  View Paper
Specifically, interference of alcohol with retinoids and cofactors of transmethylation processes are outlined.
Advances in experimental medicine and biology  •  2015  |  View Paper
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