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Last Updated: 4 months ago

Possible Interaction: Ethanol and Tretinoin

supplement:

Ethanol

supplement:

Tretinoin

Research Papers that Mention the Interaction

The perturbation of retinoic acid synthesis by ethanol may underlie the pathogenesis of fetal alcohol syndrome and alcohol-related upper digestive tract cancer.
Chemico-biological interactions  •  2003  |  View Paper
The formation of all-trans retinoic acid tended to be attenuated by 10 mM ethanol.
Alcoholism, clinical and experimental research  •  2001  |  View Paper
In summary, these studies suggest that ethanol may affect the biosynthesis of t-RA in human prenatal hepatic tissues directly and indirectly.
Biochemical pharmacology  •  1999  |  View Paper
All-trans retinoic acid deficiency resulting from ethanol ’s interference with the synthesis of all-trans retinoic acid from retinol was recently suggested to cause the malformations of the fetal alcohol syndrome.
Archives of Toxicology  •  1995  |  View Paper
Combination of RA stimulation with acute in vitro ethanol treatment, however, resulted in significantly lower M theta TGF beta production than TGF beta levels induced by RA alone (p < 0.003).
RA also induced a moderate increase in M theta tumor necrosis factor-alpha (TNF alpha) production, which was down-regulated by ethanol both at the level of secreted and cell-associated TNF alpha.
Alcoholism, clinical and experimental research  •  1994  |  View Paper
To test the hypothesis that ethanol depletes the liver of antitumor promoters such as retinoid , we measured the retinoid concentration in hepatocellular carcinoma tissues and noncancerous surrounding liver tissues in humans known to have a history of alcohol consumption.
Hepatology  •  1991  |  View Paper
Co-treatment with retinoic (0.1 nM) or folic (0.1 mM) acid with the same concentrations of ethanol resulted in significant increases in the remaining hair cells, compared to the ethanol-only treatment group, for every ethanol concentration.
Alcohol  •  2019  |  View Paper
At the cellular level, ethanol appears to inhibit Sonic hedgehog signalling, alter levels of retionoic acid activity , trigger a Ca(2+)-CamKII-dependent pathway that antagonises WNT signalling, affect cytoskeletal dynamics and increase oxidative stress.
Developmental biology  •  2016  |  View Paper
Specifically, interference of alcohol with retinoids and cofactors of transmethylation processes are outlined.
Advances in experimental medicine and biology  •  2015  |  View Paper
Actually, ethanol either has no effect on or increases atRA at select sites.
Despite this realization, insight into whether interactions between ethanol and retinoids represent cause versus effect requires additional research.
IUBMB life  •  2011  |  View Paper
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