Possible Interaction: Ethanol and Tranquilizing Agents

“An association … of tranquilizers … alcohol (prevalence ratio [PR] = 3.15; 95% confidence intervals [95%CI] 2.58-3.85), tobacco (PR = 2.61; 95%CI 2.31-… (PR = 3.70; 95%CI 3.19-4.29), and other prescription drugs (PR = 7.03; 95%CI 6.18-7.99).”

“Clinicians should monitor patients prescribed sedative or anxiolytic drugs for possible adverse events arising from concomitant use with alcohol.”

“Acute ingestion of alcohol (ethanol) with tranquilizers or hypnotics is responsible for several pharmacokinetic interactions that can have significant clinical implications.”

“Corresponding figures for the simultaneous and concurrent use of alcohol and tranquilizers were both approximately 6 million.”

“Twenty-four had been consuming minor tranquillisers together with alcohol prior to admission.”

“It was established that different tranquilizers stimulate the increase in the endogenous ethanol level as regards the spectrum of psychotropic activity.”

“While our data provide support for the suggestion that alcohol and tranquillizers may be used interchangeably by some individuals, this finding could also be an outcome of doctors' and patients' awareness of the undesirable effects of combining alcohol and tranquillizers.”

“ Alcohol interacts with many drugs frequently prescribed for older patients--antidepressants, sedatives, hypnotics, tranquilizers , and others--and the combination can sometimes be fatal.”

“The synergism between alcohol and the tranquillizers aiid barbiturates makes the combination of alcohol and drugs specially dangerous.”

“In the social sphere the interactions of different medicaments with alcohol may lead to inadvertent overdose and barbiturates, antihistamines and various tranquillisers have all been incriminated.”