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Last Updated: 3 years ago

Possible Interaction: Ethanol and Tolbutamide



Research Papers that Mention the Interaction

Rats given both ethanol and tolbutamide showed decreased oxidative phosphorylation of the myocardial mitochondria as compared with rats given only ethanol.
The concentration of acetaldehyde tended to be higher in rats given both ethanol and tolbutamide than in rats given ethanol alone.
Recent advances in studies on cardiac structure and metabolism  •  1976  |  View Paper
Hydroxytolbutamide is oxidized further in vivo by alcohol and aldehyde dehydrogenases producing carboxytolbutamide.
Methods in enzymology  •  1996  |  View Paper
Highly bound drugs with low intrinsic hepatic clearance are among the most commonly reported to have their kinetics altered by ethanol (e.g. benzodiazepines, phenytoin, tolbutamide and warfarin).
Clinical pharmacokinetics  •  1978  |  View Paper
In addition alcohol apparently potentiates insulin secretion stimulated by glucose, arginine and tolbutamide [S] .
European journal of clinical investigation  •  1978  |  View Paper
Pretreatment with tolbutamide, ethanol and tolbutamide plus ethanol resulted in protentiation of the acute phase insulin release and enhanced glucose disappearance with glucose doses of 10 gm.
Diabetes  •  1972  |  View Paper
Additional evidence is provided by the observed inhibition of tolbutamide metabolism by ethanol infusion.
Chronic addiction to alcohol produces an enhanced rate of tolbutamide metabolism; on the other hand, prolonged treatment with tolbutamide is able to increase the rate of ethanol oxidation.
European journal of clinical investigation  •  1971  |  View Paper
Summary With a sensitive technic it is demonstrated that tolbutamide (100 mg/kg) injected intravenously inhibits the metabolism of ethanol in intact cats, average inhibition being 34%.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1962  |  View Paper
Acute po administration of varying doses of tolbutamide or chlorpropamide 2.5 hr before a 3.0 g/kg ip dose of ethanol to C57BL and DBA mice resulted in significant elevations of blood acetaldehyde when measured 2.5 hr after ethanol dosing.
Measurements of aldehyde dehydrogenase (ALDH) in hepatic subcellular fractions, obtained from both inbred strains treated with 100 mg/kg tolbutamide or chlorpropamide prior to a 3.0 g/kg dose of ethanol , revealed a 50 to 80% inhibition of the low-Km ALDH present in mitochondria.
Toxicology and applied pharmacology  •  1985  |  View Paper
The oral hypoglycemic agents, chlorpropamide (CP) and tolbutamide (TB) are known to elicit a clinical disulfiram-ethanol reaction (DER) when consumed with alcohol.
Alcohol  •  1985  |  View Paper
Beaser (1958) has recorded that prior administration of tolbutamide produces an intolerance to alcohol in the form of hot flushes.
Indian journal of physiology and pharmacology  •  1964  |  View Paper
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