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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Ethanol and Ticlopidine



Research Papers that Mention the Interaction

ticlopidine (20 microM), …, respectively, decreased ethanol oxidation by 8+/-1.2% and 7.6+/-1.6% in human liver microsomal samples while selective inhibitors of CYP2E1 (DEDTC 100 … CYP1A2 (furafylline 25 microM) decreased it by 11.9+/-2.1%, 19.8+/-1.9% and 16.3+/-3.9%, respectively.
Toxicology letters  •  2006  |  View Paper
Indo, but not L-NAME, was able to significantly counteract the gastroprotective activity of ticlopidine against EtOH injury.
These results indicate that ticlopidine exerts dual effects during the development and healing of gastric lesions induced by EtOH.
Ticlopidine (30-300 mg kg(-1), os) administered 1h before EtOH dose-dependently prevented the development of gastric haemorragic lesions.
When ticlopidine was administered 1h after EtOH , it significantly (p<0.05) delays gastric lesions healing.
Pharmacological research  •  2007  |  View Paper