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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Ethanol and Ticlopidine



Research Papers that Mention the Interaction

ticlopidine (20 microM), …, respectively, decreased ethanol oxidation by 8+/-1.2% and 7.6+/-1.6% in human liver microsomal samples while selective inhibitors of CYP2E1 (DEDTC 100 … CYP1A2 (furafylline 25 microM) decreased it by 11.9+/-2.1%, 19.8+/-1.9% and 16.3+/-3.9%, respectively.
Toxicology letters  •  2006  |  View Paper
These results indicate that ticlopidine exerts dual effects during the development and healing of gastric lesions induced by EtOH.
Ticlopidine (30-300 mg kg(-1), os) administered 1h before EtOH dose-dependently prevented the development of gastric haemorragic lesions.
When ticlopidine was administered 1h after EtOH , it significantly (p<0.05) delays gastric lesions healing.
Pharmacological research  •  2007  |  View Paper