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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Ticlopidine
Research Papers that Mention the Interaction
“… ticlopidine (20 microM), …, respectively, decreased ethanol oxidation by 8+/-1.2% and 7.6+/-1.6% in human liver microsomal samples while selective inhibitors of CYP2E1 (DEDTC 100 … CYP1A2 (furafylline 25 microM) decreased it by 11.9+/-2.1%, 19.8+/-1.9% and 16.3+/-3.9%, respectively.”
Ethanol oxidation into acetaldehyde by 16 recombinant human cytochrome P450 isoforms: role of CYP2C isoforms in human liver microsomes.“Indo, but not L-NAME, was able to significantly counteract the gastroprotective activity of ticlopidine against EtOH injury.”
“These results indicate that ticlopidine exerts dual effects during the development and healing of gastric lesions induced by EtOH.”
“ Ticlopidine (30-300 mg kg(-1), os) administered 1h before EtOH dose-dependently prevented the development of gastric haemorragic lesions.”
“When ticlopidine was administered 1h after EtOH , it significantly (p<0.05) delays gastric lesions healing.”
Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat.
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