Possible Interaction: Ethanol and Thiopental

“ConclusionsBased on our tests of performance and mood, an interaction between thiopental and alcohol is evident; in addition, the interaction between both drugs may exert deleterious effects on higher levels of central nervous system integration.”

“In addition, body sway, one of the nine psychomotor tests used to assess impairment, was greater after thiopental and alcohol than after alcohol alone.”

“It was hypothesized that if patients drink alcohol 4 h after thiopental injection , the increase in psychomotor impairment would be greater than that seen after alcohol ingestion alone.”

“The results indicate cross‐tolerance between alcohol and thiopental , even when the regular intake of the former is low, and increasing thiopental requirements with increasing age.”

“The sleeping times of mice, dogs and rabbits given both thiopental and alcohol were significantly longer than the sleeping times when either of the two drugs alone were given.”

“It is concluded that chronic ethanol consumption for 14 days decreases the pharmacological effects of thiopental and alters its initial distribution in the body.”

“The simultaneous administration of ethanol at doses of either 2, 3, or 4 g/kg intraperitoneally produced a dose-related decrease in the intraperitoneal LD50 for thiopentone , pentobarbitone, amylobarbitone, phenobarbitone and barbitone in rats.”

“The simultaneous administration of ethanol at doses of either 2, 3, or 4 g/kg intraperitoneally produced a dose‐related decrease in the intraperitoneal LD50 for thiopentone , pentobarbitone, amylobarbitone, phenobarbitone and barbitone in rats.”