Possible Interaction: Ethanol and Thioguanine

“The biochemical analysis … that high-dose EE treatment increased HDL-C and decreased TC, TG , and LDL-C. Results demonstrated that high-dose EE administration protected the organ tissues from oxidative stress by normalizing the antioxidant levels, and CAT, SOD, and GSH-Px suppressed the lethal effect of MDA.”

“In Experiment 3, a direct manipulation of TG levels was found to affect ethanol intake.”

“Most importantly, ethanol and a HFD showed an interaction effect, whereby their combination produced a considerably larger increase in TG levels (+172%) compared to ethanol with a LFD (+111%).”

“Within this vicious cycle, ethanol and fat act synergistically to increase TG levels, which in turn stimulate peptides that promote further consumption, and these phenomena are reversed by gemfibrozil, which lowers TG levels.”

“It was found that 10 mg/kg of propolis ethanol extract significantly decreased the elevations of serum GOT, GPT, TG and HTG.”

“ Ethanol administration accentuated the parenchymal TG accumulation that occurs during regeneration and increased total hepatic protein content.”

“Besides the fatty acid synthesis and oxidation, ethanol also alters lipid droplet (LD, the storage form of triglycerides, TG ) metabolism in hepatocytes and very low-density lipoprotein (VLDL) secretion from liver.”

“The diffusion coefficient decreased with increasing molecular size of alcohol and proximity to Tg.”