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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
supplement:
Thiamine Pyrophosphate
Research Papers that Mention the Interaction
“In addition, there is evidence to suggest that alcohol reduces thiamine phosphorylation to thiamine pyrophosphate (TPP) in brain.”
Effects of thiamine deficiency on brain metabolism: implications for the pathogenesis of the Wernicke-Korsakoff syndrome.“ Ethanol ingestion resulted in a diminished concentration of thiamin (T), thiaminmonophosphate (TMP), thiamindiphosphate (TDP) and thiamintriphosphate (TTP) in blood and organs and in a reduced excretion rate of T in urine due to an impaired intestinal absorption.”
“These protective effects of thiamine pyrophosphate are extremely important in chronic ethanol consumption.”
The effects of thiamine pyrophosphate on ethanol induced optic nerve damage“ Ethanol consumption increased significantly the blood concentrations of pyruvate and lactate, decreased the activity of erythrocyte transketolase (TK), and increased the stimulation of TK activity of thiamin pyrophosphate (TPP) in lyzed blood cells (TPP effect).”
“ Ethanol caused a reduction of the rate of thiamine compound enzymatic transformations (T phosphorylation to TPP , TPP dephosphorylation to TMP and TMP to T), and a facilitation of the regional uptake of T and TMP, associated to a less relevant influence on their release.”
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