Possible Interaction: Ethanol and Theophylline

“ Theophylline pretreatment prior to acute ethanol administration markedly reduced the duration of ethanol-induced sleep and similarly decreased the intensity and duration of motor incoordination.”

“A monoamine oxidase inhibitor pargyline and an inhibitor of phosphodiesterase theophylline prevented the increase in adenylate deaminating activity in a subfraction of mitochondrial membranes in the ethanol intoxicated rats.”

“Mice reduced ethanol intake in the restricted access condition after receiving caffeine (20.0 mg/kg), or theophylline (20.0 mg/kg), another methylxanthine.”

“In contrast, when administered during ethanol withdrawal, theophylline (1-10 mg/kg) blocked the anti-hyperalgesic effects of ethanol during ethanol withdrawal, whereas nitrendipine (5-25 mg/kg) enabled ethanol to produce levels of antinociception comparable to non-dependent rats.”

“However, theophylline pretreatment significantly reduced ethanol-induced changes in beta-EN levels in HY, completely blocked ethanol effects in HI, and reversed ethanol alterations in MB.”

“ Ethanol (25 mM) blocked the stimulatory effect of theophylline and the results of experiments following the inclusion of adenosine deaminase suggested the involvement of adenosine in this effect of ethanol.”

“ Theophylline pretreatment prevented the increase in Bmax elicited by ethanol.”

“The increase in osmotic water flow caused by vasopressin, theophylline or cyclic adenosine-3',5'-monophosphate was inhibited by 4 to 40 mg per ml of ethanol in the mucosal or serosal bathing medium.”

“Previous studies in this laboratory demonstrated that the rate of intestinal absorption of theophylline in rats is increased significantly by ethanol in low concentrations and that this absorption enhancing effect is associated with an increased net water flux from the intestine.”

“The results show that the theophylline absorption enhancing effect of ethanol is not limited to that particular alcohol.”

“Abstract The purpose of this investigation was to deter mine directly the effect of ethanol on the absorption of theophylline from the small intestine of the rat.”

“It is concluded that the effect of ethanol on the intestinal absorption of theophylline is probably due to solvent drag, secondary to a change in water flux induced by alcohol.”

“ Theophylline absorption and water net flux were significantly increased by 2% ethanol.”

“ Theophylline absorption was significantly increased by 5% ethanol and decreased by 20% ethanol.”