Possible Interaction: Ethanol and Temazepam

“ Temazepam (15 mg) plus ethanol (peak blood concentration of 11 mmol·1−1) significantly impaired divided attention, tracking, and reaction time over a 3 h period.”

“The performance on the tracking, divided attention, and PAB reaction time tasks used in this study was impaired by a combination of Tmazepam and ethanol in doses which may not cause impairment when each is given alone.”

“The faster, more error-prone, behaviour on ethanol than with a similarly impairing dose of temazepam has clear implications for the relative potential of the two drugs to contribute to accidents.”

“The findings of the present study … that even a moderate amount of ethanol in combination with a … dose of triazolam or temazepam can cause performance impairment that might diminish an individual's ability to respond adequately … unexpected demands (e.g. smoke alarms or middle-of-the-night child care).”

“ Temazepam potentiates the CNS depressant effect ofalcohol , and VIceversa.”

“In addition to this pharmacological interaction, this report describes a novel chemical reaction between temazepam (a 3-hydroxy-1,4-benzodiazepine) and ethanol under acidic conditions similar to those found in vivo, resulting in a 3-ethoxylated product.”