Possible Interaction: Ethanol and Taurine

“Taurine sequesters HOCl from myeloperoxidase of activated leukocytes, and taurine supplementation reduced renal lipid oxidation, reduced leukocyte infiltration, and reduced the increase in myeloperoxidase-positive cells during ethanol feeding.”

“The results indicated that taurine administered alone or together with traditional Chinese medicine could significantly accelerate the metabolism of alcohol , reduce the toxicity of alcohol, and coadministration of taurine and traditional Chinese medicine had better effects.”

“The results showed that taurine administered alone or together with Chinese traditional medicine could both significantly reduce the number of intoxicated mice, postpone the tolerance time, shorten the maintenance time, and could obvisouly decrease blood level of alcohol , increase hepatic levels of ADH and ALDH.”

“Behavioral evidence suggests that taurine can alter the locomotor stimulatory, sedating, and motivational effects of ethanol in a strongly dose-dependent manner.”

“Finally, taurine and several related molecules including the homotaurine derivative acamprosate (calcium acetylhomotaurinate) can reduce ethanol self-administration and relapse to drinking in both animals and humans.”

“Microdialysis studies have revealed that ethanol elevates extracellular levels of taurine in numerous brain regions, although the functional consequences of this phenomenon are currently unknown.”

“Although alcohol did not affect the urinary excretion of taurine (a non-invasive marker of liver damage), levels of serum and hepatic taurine were markedly raised in animals given taurine following their treatment with alcohol , compared to animals given taurine alone.”

“There was evidence of slight bile duct injury in animals treated with alcohol and with alcohol followed by taurine , as indicated by raised serum alkaline phosphatase (ALP) and cholesterol.”

“A small ET dose is not enough to alter ABP in all regions of the frontal cortex and, in combination with TA , it showed an increase in the frontal cortex activity at the post-exercise moment.”

“ Alcohol also reduces the transport of taurine , which is vital for developmental neurogenesis.”

“ Alcohol inhibited taurine transport in BeWo cells at 10 mM and 40 mM (p<0.05; N = 6), and in placenta at 40 mM (p<0.05; N = 7).”

“Little noticed clinical studies conducted nearly three decades ago reported that pre-ingestion of either taurine or pantethine could blunt the rise in blood acetaldehyde following ethanol consumption.”

“Indeed, in the comparable case of energy drinks, which contain copious amounts of caffeine, as well as amino acids such as taurine , and are also classified as dietary supplements, it was their increasing use with alcohol that caused much alarm in the medical and scientific communities.”

“The cellular targets of the antagonism between Mg, taurine and ethanol are particularly intercellular spaces and podocytes.”

“All TAU concentrations counteracted EtOH 1%-induced locomotion impairment, as well as the anxiogenic-like behavior.”

“Although TAU has a neuroprotective role in the brain, the putative risks of mixing TAU and EtOH are not fully understood.”

“Finally, all TAU concentrations when given independently or cotreated with EtOH 0.25% and 1% decreased the risk assessment of the lit compartment.”

“Overall, we demonstrate that TAU differently modulates EtOH-induced anxiolytic- and anxiogenic-like behaviors depending on the concentration, suggesting a complex mechanism underlying TAU and EtOH interactions.”