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Last Updated: 2 months ago

Possible Interaction: Ethanol and Tamoxifen

supplement:

Ethanol

Research Papers that Mention the Interaction

Correspondingly, alcohol treatment attenuated the anti-proliferative effects of the endocrine therapeutic drug tamoxifen in ER-positive breast cancer cells.
PloS one  •  2015  |  View Paper
Tamoxifen also reduced EtOH consumption in male mice and this action was inhibited by GW9662, but not MK886, suggesting that it acts by activation of PPARγ.
Alcoholism, clinical and experimental research  •  2016  |  View Paper
The findings from this work demonstrate the ability of 1,8‐cineole and ethanol to enhance the in‐vitro permeation of tamoxifen and GLA across the skin and support the plausibility of simultaneously delivering tamoxifen and GLA transcutaneously as a two‐pronged anti‐breast cancer system.
The Journal of pharmacy and pharmacology  •  2004  |  View Paper
The flux of tamoxifen with menthone in combination with 50% EtOH was significantly greater (P<0.05) than the control (50% EtOH).
International journal of pharmaceutics  •  2001  |  View Paper
Furthermore, tamoxifen inhibited suppression of ethanol on LH pulse was observed in the control and fasting heifers injected with tamoxifen dissolved in ethanol.
Theriogenology  •  1999  |  View Paper
The above terpenes (5% w/v) in combination with 50% ethanol significantly (P < 0.01) increased the permeability coefficient of tamoxifen in comparison to the control (50% ethanol).
Journal of controlled release : official journal of the Controlled Release Society  •  1998  |  View Paper
Short-term pretreatment with tamoxifen prior to an acute sedative dose of ethanol potentiated ethanol-medicated behavioral depression in the mouse.
General pharmacology  •  1990  |  View Paper