Possible Interaction: Ethanol and Sulforaphane

“These new experimental findings implicate down-regulation of the Nrf2-ARE signaling pathway as a fundamental mechanism … which alcohol causes profound oxidative stress and alveolar epithelial dysfunction, and suggest that treatments, such as sulforaphane , that activate this pathway could … the pathophysiological consequences of alcohol on the lung … other organs.”

“ Sulforaphane , a cruciferous vegetable-derived activator of Nrf2, significantly attenuated acute ethanol intoxication.”

“This study suggests that SFN , in appropriate concentrations, could be a potential candidate compound for preventing the negative impact of alcohol on angiogenesis.”

“ChIP‐qPCR assay revealed that ethanol exposure significantly decreased acetyl‐histone H3 binding to the Bcl‐2 promoter while supplementing with SFN reversed the ethanol‐induced reduction in acetyl‐histone H3 binding to the Bcl‐2 promoter.”

“ SFN increased the levels of acetylated histone H3 in NCCs exposed to ethanol.”

“Treatment with SFN also significantly diminished apoptosis in mouse embryos exposed to ethanol in vivo.”

“We also found that SFN treatment significantly increased the expression of acetyl‐histone H3 in NCCs treated with ethanol.”

“The effect of alcohol on TGFβ1 is mitigated by treatment with sulforaphane (SFP), which can activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2).”

“Treatment with SFP mitigated the effect of alcohol on miR-21, Smad7 and total and phosphorylated STAT3, and restored Nrf2-regulated antioxidant gene expression.”

“We also found that ethanol exposure induced hypermethylation at the promoter regions of two inhibitor of apoptosis proteins (IAP), NAIP and XIAP, in hNCCs, which were prevented by co-treatment with SFN.”