Possible Interaction: Ethanol and Sucralfate

“ Ethanol produces pronounced mucosal damage that can be almost completely prevented by sucralfate.”

“ Sucralfate was relatively more effective in mucosal protection against ethanol when given at lower pH (1 or 2) than at original pH (4.5) and failed to protect at neutral pH (7.0).”

“In both the fundus and the antrum, the mean endoscopic injury score after sucralfate plus ethanol administration was significantly lower than that after ethanol alone.”

“ Sucralfate has been shown to increase mucosal resistance to damaging agents, such as ethanol and aspirin.”

“It was found that sucralfate was effective in preventing gastric lesions induced by ethanol.”

“Our results indicate that sucralfate has a protective effect on gastric lesions induced by ethanol and omeprazole applied i.p.”

“Similarly, sucralfate (0.031-0.250 g/kg) orally and allopurinol (0.025-0.050 g/kg) intravenously inhibited vascular permeability caused by ethanol and treatment with N-ethylmaleimide before sucralfate or allopurinol reduced their inhibitory effects.”

“Both honey and sucralfate dose-dependently afforded protection against gastric damage and reversed the changes in glandular NP-SH levels induced by ethanol.”

“an inhibitor of NO synthase, dose-dependently enhanced the mucosal damage by ethanol itself and reduced the protective effects of sucralfate and Maalox but not those of sofalcone, De-Nol or nocloprost against the ethanol injury.”

“The changes in mucin and phosphoinositide distribution patterns evoked by ethanol were prevented by sucralfate.”

“The damaging effects on mucosa of nicotine and ethanol , alone or in combination, were reduced by pretreatment with sucralfate.”