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Possible Interaction: Ethanol and Sucralfate

supplement:

Ethanol

Research Papers that Mention the Interaction

Ethanol produces pronounced mucosal damage that can be almost completely prevented by sucralfate.
The American journal of medicine  •  1989  |  View Paper
Sucralfate was relatively more effective in mucosal protection against ethanol when given at lower pH (1 or 2) than at original pH (4.5) and failed to protect at neutral pH (7.0).
Scandinavian journal of gastroenterology  •  1989  |  View Paper
In both the fundus and the antrum, the mean endoscopic injury score after sucralfate plus ethanol administration was significantly lower than that after ethanol alone.
Gastroenterology  •  1989  |  View Paper
Sucralfate has been shown to increase mucosal resistance to damaging agents, such as ethanol and aspirin.
Scandinavian journal of gastroenterology. Supplement  •  1992  |  View Paper
It was found that sucralfate was effective in preventing gastric lesions induced by ethanol.
Our results indicate that sucralfate has a protective effect on gastric lesions induced by ethanol and omeprazole applied i.p.
Wiener klinische Wochenschrift  •  1998  |  View Paper
Similarly, sucralfate (0.031-0.250 g/kg) orally and allopurinol (0.025-0.050 g/kg) intravenously inhibited vascular permeability caused by ethanol and treatment with N-ethylmaleimide before sucralfate or allopurinol reduced their inhibitory effects.
Journal of ethnopharmacology  •  1997  |  View Paper
Both honey and sucralfate dose-dependently afforded protection against gastric damage and reversed the changes in glandular NP-SH levels induced by ethanol.
Tropical gastroenterology : official journal of the Digestive Diseases Foundation  •  1995  |  View Paper
an inhibitor of NO synthase, dose-dependently enhanced the mucosal damage by ethanol itself and reduced the protective effects of sucralfate and Maalox but not those of sofalcone, De-Nol or nocloprost against the ethanol injury.
Journal of clinical gastroenterology  •  1993  |  View Paper
The changes in mucin and phosphoinositide distribution patterns evoked by ethanol were prevented by sucralfate.
The American journal of medicine  •  1991  |  View Paper
The damaging effects on mucosa of nicotine and ethanol , alone or in combination, were reduced by pretreatment with sucralfate.
Gut  •  1991  |  View Paper
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