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Last Updated: 2 years ago

Possible Interaction: Ethanol and Substance P



Research Papers that Mention the Interaction

Specifically, substance P (SP) and neurokinin B (NKB), have been shown to influence responses to alcohol , cocaine, and/or opiate drugs.
Brain Research  •  2020  |  View Paper
Adolescence is a critical developmental period of high vulnerability in which ethanol exposure alters corticotropin releasing factor, neuropeptide Y, substance P and neurokinin neuropeptide activities, all of which have key roles in ethanol consumption.
Pharmacology Biochemistry and Behavior  •  2013  |  View Paper
Given the selective reductions on alcohol (compared to sucrose) responding by direct intracranial infusion of SP , the data suggest that deficits in SP signaling within the CeA (an anxiety regulating locus) are inversely associated with alcohol‐motivated behaviors.
The results revealed that, when infused into the CeA (1–8 μg), SP reduced alcohol responding by 48–85% of control levels, with no effects on sucrose responding.
Synapse  •  2009  |  View Paper
Coadministration of low, innocuous doses of EtOH and SP caused lesions by a TRPV1-independent but neurokinin 1 receptor-dependent process.
Free radical biology & medicine  •  2007  |  View Paper
Perfusion with 50% ethanol for 5 min increased the SP levels approximately threefold.
Journal of Gastroenterology  •  2006  |  View Paper
Substance P and vasoactive intestinal peptide (VIP) levels were significantly higher in the damaged mucosa in rats treated with ethanol , as was the mucosal generation of leukotriene B4 (LTB4) and cysteinyl-containing leukotrienes.
Digestive Diseases and Sciences  •  2005  |  View Paper
The effects of kainate (0.5 μM), AMPA (0.3 μM) and nicotine (1 μM) were also depressed by ethanol (100 μM), while the effects of substance P (0.03 μM) and α,β-meATP (30 μM) were not changed.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Intraventricular administration of SP (1 μg/rat) decreased consumption of 10% ethanol solution by 41% compared with controls in an alcohol free choice test lasting one day.
Thus, central administration of SP decreased the voluntary consumption of ethanol in the ethanol free choice test and enhanced dopamine metabolism in structures of the mesolimbic and nigrostriatal systems in chronically alcoholic rats.
Neuroscience and Behavioral Physiology  •  2004  |  View Paper
Substance P antagonist, lidocaine or atropine given alone, prevented mucosal damage; however, only substance P antagonist enhanced the anti‐lesion action of 20% ethanol , while atropine and lidocaine increased the protective effect of NaCl and HCl.
Journal of gastroenterology and hepatology  •  1994  |  View Paper
The data obtained suggest that the substance P is able to increase a tolerance of the central mechanisms of biological motivations of ethanol.
Fiziologicheskii zhurnal imeni I.M. Sechenova  •  1992  |  View Paper
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