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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Substance P
Research Papers that Mention the Interaction
“Specifically, substance P (SP) and neurokinin B (NKB), have been shown to influence responses to alcohol , cocaine, and/or opiate drugs.”
Neurokinin receptors in drug and alcohol addiction“Adolescence is a critical developmental period of high vulnerability in which ethanol exposure alters corticotropin releasing factor, neuropeptide Y, substance P and neurokinin neuropeptide activities, all of which have key roles in ethanol consumption.”
Adolescent binge-like ethanol exposure reduces basal α-MSH expression in the hypothalamus and the amygdala of adult rats“Given the selective reductions on alcohol (compared to sucrose) responding by direct intracranial infusion of SP , the data suggest that deficits in SP signaling within the CeA (an anxiety regulating locus) are inversely associated with alcohol‐motivated behaviors.”
“The results revealed that, when infused into the CeA (1–8 μg), SP reduced alcohol responding by 48–85% of control levels, with no effects on sucrose responding.”
“Coadministration of low, innocuous doses of EtOH and SP caused lesions by a TRPV1-independent but neurokinin 1 receptor-dependent process.”
“Perfusion with 50% ethanol for 5 min increased the SP levels approximately threefold.”
“ Substance P and vasoactive intestinal peptide (VIP) levels were significantly higher in the damaged mucosa in rats treated with ethanol , as was the mucosal generation of leukotriene B4 (LTB4) and cysteinyl-containing leukotrienes.”
“The effects of kainate (0.5 μM), AMPA (0.3 μM) and nicotine (1 μM) were also depressed by ethanol (100 μM), while the effects of substance P (0.03 μM) and α,β-meATP (30 μM) were not changed.”
“Intraventricular administration of SP (1 μg/rat) decreased consumption of 10% ethanol solution by 41% compared with controls in an alcohol free choice test lasting one day.”
“Thus, central administration of SP decreased the voluntary consumption of ethanol in the ethanol free choice test and enhanced dopamine metabolism in structures of the mesolimbic and nigrostriatal systems in chronically alcoholic rats.”
“Substance P antagonist, lidocaine or atropine given alone, prevented mucosal damage; however, only substance P antagonist enhanced the anti‐lesion action of 20% ethanol , while atropine and lidocaine increased the protective effect of NaCl and HCl.”
“The data obtained suggest that the substance P is able to increase a tolerance of the central mechanisms of biological motivations of ethanol.”
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