Possible Interaction: Ethanol and Steroids

“When necessary, ethanol or salbutamol infusions were used to delay delivery while steroid or placebo therapy was given.”

“Acute, but not chronic ethanol administration elevates brain levels of these steroids and enhances GABA(A) receptor activity.”

“These results suggest the possible synergic action between endogenous steroids and ethanol in modulating the functional activity of specific neuronal populations.”

“The results demonstrate that, in the presence of the steroid , 0.05 % (9 mm) ethanol potentiates the GABAA receptor function by increasing the channel mean open duration.”

“Several lines of evidence indicate that female sex steroids , especially estrogen, interact with ethanol pharmacokinetics.”

“BACKGROUND Caffeine, alcohol , smoking and physical activity are known to alter sex steroid synthesis, which may affect hormone-dependent gynaecologic disease risk, such as endometriosis; however, few studies have assessed life style factors prior to endometriosis diagnosis.”

“We note that for women, the effects of alcohol on these neuroendocrine stress regulation systems may be influenced by the rhythmic variations of hormones and steroids across the menstrual cycle.”

“Intra-tissue levels of steroid hormones (e.g., dehydroepiandrosterone [DHEA], pregnenolone [PREGN], and testosterone [T]) may influence the pathological changes seen in neurotransmitter systems of alcoholic brains.”

“Increased alcohol usage may be exerting its effect through subtle changes in steroid hormones (particularly estrogen).”

“When necessary, ethanol or salbutamol infusions were used to delay delivery while steroid or placebo therapy was given.”