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Last Updated: 3 years ago

Possible Interaction: Ethanol and St John's Wort




St John's Wort

Research Papers that Mention the Interaction

During treatment alcohol intake was monitored .In present finding chronic administration of SJW significantly reduced ethanol intake by 78.6% (P<0.001) in mice.
Pakistan journal of pharmaceutical sciences  •  2018  |  View Paper
HPE (25–200 mg/kg) produced some dose‐dependent and significant inhibitory effects on locomotor hyperactivity at second and sixth hour of ethanol withdrawal.
These results suggest that HPE has some beneficial effects on ethanol withdrawal syndrome in rats.
Fundamental & clinical pharmacology  •  2006  |  View Paper
AIMS Recent studies have shown that Hypericum perforatum extracts (HPE) inhibit ethanol intake in alcohol-preferring rats, but their mechanism of action is still unknown.
Alcohol and alcoholism  •  2002  |  View Paper
Hypericum perforatum extracts (HPE) inhibit ethanol intake in rats.
Moreover, different neurochemical mechanisms are apparently responsible for the reduction of ethanol intake and for the antidepressant-like effect of HPE.
Alcohol and alcoholism  •  2001  |  View Paper
In rats offered 10% ethanol … 12 h/day, ethanol intake following treatment … 250 mg/kg HPE was significantly lower than that of controls for up to 10 h. The effect on ethanol intake was not related to the antidepressant-like effect of HPE revealed in the forced swimming test.
administration of HPE , 125 or 250 mg/kg, induced a 30-40% reduction in ethanol intake in rats offered 10% (v/v) ethanol for 2 h/day.
Alcohol and alcoholism  •  1999  |  View Paper