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Last Updated: 2 years ago

Possible Interaction: Ethanol and Sphingosine 1-Phosphate



Research Papers that Mention the Interaction

Further evidence indicates that Toh is involved in the trafficking or cellular release of S1P.
Current Biology  •  2008  |  View Paper
S1P also ameliorated the decreased DNA synthesis of cells induced by ethanol.
Hepatology  •  2006  |  View Paper
Cotreatment of fibroblasts with ethanol for 10 min also enhanced the stimulatory effects of S1P on the activities of c-Raf-1 kinase and p70 S6 kinase, but neither S1P nor ethanol had effects on phosphatidylinositol 3'-kinase and Akt/PKB kinase activities.
In mouse embryo NIH 3T3 fibroblasts, ethanol (60-80 mM) was found to enhance the stimulatory effects of sphingosine 1-phosphate (S1P) on both DNA synthesis and cell proliferation.
Of the various growth regulatory enzymes examined, ethanol detectably enhanced the stimulatory effects of S1P on the phosphosphorylation (activation) of p42/p44 mitogen-activated protein (MAP) kinases, but not of p38 MAP kinase.
The results indicate that in NIH 3T3 fibroblasts, ethanol can enhance the mitogenic effects of S1P by a zinc- and calcium-dependent mechanism involving both the rapamycin-sensitive p70 S6 kinase-dependent and the c-Raf-1/MAP kinase-dependent growth regulatory pathways.
Archives of biochemistry and biophysics  •  1999  |  View Paper
Among the lipophilic analogs in [L-Glu6] derivatives, the C6 alcohol ester showed the strongest antifungal activity against Candida spp.
The Journal of antibiotics  •  1998  |  View Paper