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“The activity shown by a series of commercially available polyamines (putrescine (Pu), spermidine (SPD) and spermine SP )) in inhibiting voluntary ethanol intake lends support to our hypothesis.”
“Recent evidence suggests that elevations in the synthesis and release of the polyamines spermidine and spermine , which are known modulators of NMDARs, contribute to the increased activity of the receptor during ethanol withdrawal.”