Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Ethanol and Sincalide



Research Papers that Mention the Interaction

Whereas, in response to 1 nM CCK-8 , the total Ca2+ mobilization was significantly increased by ethanol pre-treatment.
BMC Cell Biology  •  2009  |  View Paper
After stimulation of cells with CCK-8 or Tps in the presence of 50mM ethanol , a greater [Ca2+]c peak response, a slower rate of decay of [Ca2+]c, and higher values of [Ca2+]c were observed.
In the presence of 50mM ethanol, CCK-8 lead to a greater Ca2+ mobilization compared to that obtained with CCK-8 alone.
The actions of ethanol on CCK-8 stimulation of cells create a situation potentially leading to Ca2+ overload, which is a common pathological precursor that mediates pancreatitis.
Alcohol  •  2008  |  View Paper
In contrast, incubation of cells with 50mM ethanol clearly reduced amylase release stimulated by CCK-8.
Alcohol  •  2006  |  View Paper
CCK-8 …% ethanol ingestion; (2) this inhibitory effect of CCK-8 on ethanol intake appeared behaviorally similar to its inhibitory action on ingestion of sucrose solutions; (… (5) antagonism of CCK1 receptors with devazepide increased ethanol intake, indicating that endogenous CCK normally limits the size of bouts of ethanol ingestion.
Peptides  •  2004  |  View Paper
Analyses of variance revealed a significant (P<.05) effect of CCK, and a significant interaction of CCK and TRH in control of ethanol consumption.
Thyrotropin-releasing hormone (TRH) and cholecystokinin octapeptide (CCK) are endogenous neuropeptides known to inhibit intake of alcohol.
Physiology & Behavior  •  2004  |  View Paper
The combined action of ethanol and CCK-8 results in NF-kappaB activation and up-regulation of proinflammatory cytokines and chemokines in the pancreas.
Gastroenterology  •  1999  |  View Paper
The protective effects of leptin, CCK-8 and PGE2 were accompanied by significant attenuation of the fall of the GBF caused by ethanol.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  1999  |  View Paper
Ethanol had no influences on the initial rise but increased the sustained rise in [Ca2+]i stimulated by CCK-8 and inhibited CCK-8-stimulated Ca2+ outflux without affecting Ca2+ influx.
On the other hand, ethanol inhibited only the sustained phase of amylase release stimulated by CCK-8.
Pancreas  •  1996  |  View Paper
Injection of CCK-8 or BBS-14 significantly and equivalently suppressed intake of ethanol and food at 30 min after presentation in each group of rats.
Alcoholism, clinical and experimental research  •  1993  |  View Paper
These results are consistent with the hypothesis that EtOH , when taken on a chronic basis, increases the sensitivity to CCK-8.
The American journal of physiology  •  1993  |  View Paper
Show More