“Therefore, whenever xenobiotics that are substrates …, paracetamol (acetaminophen), halothane, enflurane, methoxyflurane, sevoflurane and many organic solvents (e.g. aniline, … individual who is also chronically consuming ethanol , the accelerated metabolism of these agents and their clinical impact (e.g. …) and toxicological impact (accumulation of active metabolites) have to be considered.”