Possible Interaction: Ethanol and Serotonin Agents

“Furthermore, ethanol is also involved in the disruption of serotonergic and adrenergic pathways in amnestic alcoholics (Charness et al., 1989).”

“We identified four serotonergic neurons that inhibit the olfactory attraction to ethanol and two additional neurons that counteract this inhibition by strengthening olfactory information.”

“Effects on these channels, as well as glycine, nicotinic cholinergic, serotonergic , and other ion channels, likely contribute to the euphoric, sedative, and other acute actions of ethanol.”

“Our results suggest that the 5-HT1B receptor participates in the regulation of ethanol drinking, and demonstrate that serotonergic manipulations lead to reduced responsiveness to certain ataxic effects of ethanol without affecting dependence.”

“ Alcohol can potentiate the opening of 5-HT3 receptor ion channels, and agents which elevate serotonergic tone, including serotonergic agonists, uptake inhibitors and releasers, have shown promise in assisting with recovery from alcoholism.”

“This research examined the possibility that ethanol directly impairs the development of serotonergic neurons.”

“SMK + ETOH deprivation evokes serotonergic disruption that is at least equivalent to that caused by either drug alone.”

“Prenatal ethanol exposure causes the reduction of serotonergic (5‐HTergic) neurons in the midbrain raphe nuclei.”

“In addition, withdrawal from alcohol exacerbates serotonergic functions that results in failure to suppress corticosterone levels and hence induce low mood states and other signs and symptoms of alcohol withdrawal syndrome.”

“Systemic ethanol treatment dose-dependently attenuated photic and serotonergic phase-resetting.”