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Last Updated: 3 years ago

Possible Interaction: Ethanol and Secretin





Research Papers that Mention the Interaction

Pancreatitis inducing agents like bile acids and ethanol dose-dependently affect pancreatic ductal secretion ; low concentrations stimulate, whereas high concentrations inhibit secretion.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]  •  2015  |  View Paper
2) The long term ethanol administration tended to decrease the amounts of gastrin, secretin and cholecystokinin contained in the gastrointestinal mucosa.
Gastroenterologia Japonica  •  2007  |  View Paper
In man plasma secretin levels increased significantly from a basal of 121 +/- 14 to 164 +/- 24 pg/ml at 60 minutes after oral ingestion of alcohol.
Surgery  •  1977  |  View Paper
Pancreatic insulin secretion may play a more important role than insulin resistance in the relationship between alcohol and incidence of DM.
Archives of medical research  •  2019  |  View Paper
It has also been postulated that alcohol may cause an increase in iron absorption through stimulation of gastric acid secretin.
The Medical journal of Australia  •  1972  |  View Paper
Ethanol at 0.3‐30 mM significantly augmented fluid secretion stimulated by physiological (1 pM) or pharmacological (1 nM) concentrations of secretin.
Ethanol at 1 mM shifted the secretin concentration‐fluid secretion response curve upwards and raised the maximal secretory response significantly by 41 %.
In conclusion, low concentrations of ethanol directly augment pancreatic ductal fluid secretion stimulated by physiological and pharmacological concentrations of secretin , and this appears to be mediated by the activation of both the intracellular cAMP pathway and Ca2+ mobilization.
The Journal of physiology  •  2003  |  View Paper
Moreover, 4-hour pre-infusion of ethanol caused a significant increase in pancreatic cathepsin B output stimulated by caerulein (0.2 microgram/ and secretin (0.2 CU/ compared with the control rats.
Nihon geka hokan. Archiv fur japanische Chirurgie  •  1993  |  View Paper
Plasma secretin levels also augmented after the administration of ethanol solutions, with a delay of about one hour after the onset of acid secretion.
The Tohoku journal of experimental medicine  •  1985  |  View Paper
Integrated secretin release after a meal, 4.5 +/- 0.7 ng/ml-2 hr, had also increased significantly to 7.6 +/- 1.3 ng/ml-2 hr when ethanol was given in addition to a meal.
Surgery  •  1984  |  View Paper
Long-term administration of ethanol seemed to induce a dose-related increase of the protein response to secretin , the maximal output being 30.9 mg/10 min.
Six months' alcohol treatment thus increased the secretory capacity of the pancreas in response to secretin.
Scandinavian journal of gastroenterology  •  1982  |  View Paper
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