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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Pancreatitis inducing agents like bile acids and ethanol dose-dependently affect pancreatic ductal secretion ; low concentrations stimulate, whereas high concentrations inhibit secretion.”
The role of pancreatic ducts in the pathogenesis of acute pancreatitis.“2) The long term ethanol administration tended to decrease the amounts of gastrin, secretin and cholecystokinin contained in the gastrointestinal mucosa.”
“In man plasma secretin levels increased significantly from a basal of 121 +/- 14 to 164 +/- 24 pg/ml at 60 minutes after oral ingestion of alcohol.”
“ Pancreatic insulin secretion may play a more important role than insulin resistance in the relationship between alcohol and incidence of DM.”
“It has also been postulated that alcohol may cause an increase in iron absorption through stimulation of gastric acid secretin.”
“ Ethanol at 0.3‐30 mM significantly augmented fluid secretion stimulated by physiological (1 pM) or pharmacological (1 nM) concentrations of secretin.”
“ Ethanol at 1 mM shifted the secretin concentration‐fluid secretion response curve upwards and raised the maximal secretory response significantly by 41 %.”
“In conclusion, low concentrations of ethanol directly augment pancreatic ductal fluid secretion stimulated by physiological and pharmacological concentrations of secretin , and this appears to be mediated by the activation of both the intracellular cAMP pathway and Ca2+ mobilization.”
Ethanol induces fluid hypersecretion from guinea‐pig pancreatic duct cells“Moreover, 4-hour pre-infusion of ethanol caused a significant increase in pancreatic cathepsin B output stimulated by caerulein (0.2 microgram/kg.hr) and secretin (0.2 CU/kg.hr) compared with the control rats.”
“Plasma secretin levels also augmented after the administration of ethanol solutions, with a delay of about one hour after the onset of acid secretion.”
“Integrated secretin release after a meal, 4.5 +/- 0.7 ng/ml-2 hr, had also increased significantly to 7.6 +/- 1.3 ng/ml-2 hr when ethanol was given in addition to a meal.”
“Long-term administration of ethanol seemed to induce a dose-related increase of the protein response to secretin , the maximal output being 30.9 mg/10 min.”
“Six months' alcohol treatment thus increased the secretory capacity of the pancreas in response to secretin.”
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