Possible Interaction: Ethanol and Salvia Miltiorrhiza

“These results a) demonstrate that treatment with S. miltiorrhiza extract selectively reduced the reinforcing and motivational properties of alcohol in sP rats and b) extend to operant procedures of alcohol self-administration previous data on the "anti-alcohol" effects of S. miltiorrhiza extracts.”

“Consistently, the results of Experiment 4 of … that a combination of 200 mg/kg Salvia miltiorrhiza extract IG and … g/kg ethanol IG resulted in a partial blockade of the discriminative stimulus effects of ethanol in … to discriminate these doses of ethanol from water in a drug discrimination procedure.”

“Intragastric administration of 200 mg/kg Salvia miltiorrhiza extract resulted in approximately 40% reduction in ethanol intake and preference throughout the 4-day treatment.”

“The reducing effect of Salvia miltiorrhiza extract on ethanol absorption may have therefore resulted in an attenuated perception of the psychoactive effects of ethanol sought by ethanol-drinking rats.”

“This effect of Salvia miltiorrhiza extract was likely due to its ability of altering ethanol absorption from the gastrointestinal tract.”

“Therefore, these results suggest that SM prevents ethanol-induced amnesia by protecting the hippocampus from NMDA receptor-mediated synaptic transmission and synaptic plasticity deficits induced by ethanol.”