Possible Interaction: Ethanol and Salicylic Acid

“It was found that the tricylic antidepressant added to the deleterious effects of alcohol.”

“ Sodium salicylate (SA) has been reported to inhibit the formation of gastric ulcerations induced by aspirin, indomethacin, and absolute ethanol.”

“Our findings suggest that salicylate may substantially inhibit hepatic FPM of alcohol at both the ADH and ALDH steps when concurrent intaking aspirin.”

“However, the decreased permeation of salicylate ion observed at higher volume fractions of ethanol may be attributed to decreased uptake of permeant into the stratum corneum.”

“ SCS shortened the sedative-hypnotic effects of ethanol and diazepam but not of propofol.”

“It was also shown that treatment with NIF1 or 23-HTA reduced gastric lesion extent, acidity and total gastric acid output induced by EtOH plus sodium salicylate in a gastric secretion test.”

“…%ethanol induced severe gastric mucosal damage (lesion index 39 +/- 0.8), which was substantially but …,16-dimethyl-prostaglandin (PG) E(2) (75 ng/kg), 20% ethanol (1 ml), sodium salicylate (15 mg/kg), the metal salt lithium chloride (7 mg/… mg/kg), and the thiol dimercaprol (10 mg/kg).”

“In conclusion, addition of ethanol to a drug solution at an appropriate concentration was proved to enhance the iontophoretic transdermal delivery of SA.”

“A combined administration of sodium salicylate and ethanol to female rats in threshold embryotoxic doses on the 9th, 10th, 12th and 13th days of pregnancy results in a sharp increase of embryolethal and teratogenic effects.”

“The embryotoxic effect of sodium salicylate and ethanol at their combined injection exceeds the summational embryotoxic effect at the separate action of the preparations.”

“On the other hand, sodium salicylate , but not indomethacin or low doses of aspirin (up to 25 mg kg−1), by an unknown mechanism inhibits stimulation of LTC4 biosynthesis by ethanol and simultaneously protects the gastric mucosa against ethanol‐induced damage.”