Possible Interaction: Ethanol and S-Adenosylmethionine

“This review describes the protection by SAM against alcohol and cytochrome P450 2E1-dependent cytotoxicity both in vitro and in vivo and evaluates mechanisms for this protection.”

“Reduction of proteasome activity of hepatoma cell and hepatocytes by ethanol or tubercidin was prevented by simultaneous treatment with S-adenosylmethionine (SAM).”

“ Ethanol alters hepatic methionine metabolism, leading to perturbation of S-adenosylmethionine-dependent transmethylation.”

“Folate deficiency alone reduced hepatic folates by one half, and ethanol feeding alone reduced methionine synthase, S-adenosylmethionine (SAM), and glutathione (GSH) levels and elevated plasma malondialdehyde (MDA) levels.”

“ S-Adenosyl-L-methionine has been shown to attenuate liver injury caused by alcohol and other hepatotoxins in some animal models.”

“Understanding the mechanisms by which SAMe attenuates liver injury caused by alcohol may provide useful information for full-scale human clinical trials.”

“ Alcohol feeding resulted in hepatic steatosis (without fibrosis) and unchanged SAMe synthetase activity, yet SAMe concentration was already greatly decreased.”

“Supplementation of S-adenosyl-L-methionine (SAM) to rats fed alcohol chronically has been shown to replete the mitochondrial GSH levels because of normalization of the microviscosity of the mitochondrial inner membrane.”

“ SAMe is particularly important in opposing the toxicity of free oxygen radicals generated by various pathogens, including alcohol , which cause oxidative stress largely by the induction of cytochrome P4502E1 (CYP2E1) and by its metabolite acetaldehyde.”

“In human healthy volunteers it has been recently demonstrated that SAMe , after ethanol ingestion, significantly lowers plasma concentration of ethanol and acetaldehyde as well.”

“Objective: Simultaneous alcohol and cannabis (i.e., marijuana [ SAM ]) use is highly prevalent among young adults and college students and associated with a number of negative consequences compared to single substance use.”