supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Ethanol
drug:
Rimonabant
Research Papers that Mention the Interaction
“ Rimonabant also reduced resumption of cocaine-seeking responses and may also reduce ethanol and opiate-seeking behavior.”
Rehabilitating rimonabant“The cannabinoid CB(1) antagonist/inverse agonist rimonabant has been shown to reduce the behavioral effects of stimuli associated with drugs of abuse, including nicotine, alcohol , cocaine, and marijuana.”
“Naloxone and rimonabant block neurotransmitter action of some drugs of abuse (such as ethanol , opiates, and nicotine), and thereby reduce drug seeking and self-administration by suppressing the drugs' reinforcing properties.”
Naloxone and rimonabant reduce the reinforcing properties of exercise in rats.“Thus, rimonabant possibly enhances an endogenous response generated by interrupting the regular use of alcohol.”
“ Rimonabant (0.0, 0.3, 1.0 and 3.0 mg/kg) significantly reduced ethanol self-administration.”
“of single 2.5 and 5.0-mg/kg doses of rimonabant preferentially reduced ethanol intake, whereas a 10 mg/kg dose of rimonabant similarly reduced both ethanol and food intake.”
“ Rimonabant (3 or 10 mg/kg) altered the locomotor effect of alcohol in a biphasic manner.”
“These results suggest that rimonabant can prevent the relapse to alcohol , even when an interaction with nicotine exists-the most frequent situation in human alcohol abuse.”
“ Rimonabant may selectively reduce responding for an ethanol solution compared with an alternative.”
“Antagonism of the CB(1) cannabinoid receptor (CB(1) receptor) by rimonabant (SR141716) reduces self-administration of alcohol and other drugs of abuse in animal models.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback