Possible Interaction: Ethanol and Riboflavin

“A nutrient, such as alcohol , can prevent adequate digestion as well as absorption of another nutrient, such as riboflavin , when present in the form in food as flavin adenine dinucleotide, or FAD.!”

“The ethanol toxicity was also prevented by radical trapping agents such as N-acetylcysteine and N-t-butyl-α-phenylnitrone, antioxidative agents such as catalase, superoxide dismutase, thiourea, and uric acid, and inhibitors of lipid peroxidation, such as vitamin E phosphate , Trolox, and diphenylphenylenediamine.”

“In subsequent studies with mucosal cell extracts, ethanol markedly inhibited activities of FAD pyrophosphatase and flavin mononucleotide (FMN) phosphatase.”

“These findings suggest that dietary sources of riboflavin (FMN and FAD) are not absorbed as well in the presence of ethanol than are vitamin preparations containing riboflavin, which is utilized more readily.”

“The authors' previous studies have shown that hepatic steatosis of chronic ethanol ingestion in rats can be prevented by adding pyruvate, dihydroxyacetone, and riboflavin to their diet.”

“Results showed that probable alcohol , malic acid, color intensity and hue had significant differences when the riboflavin treatments were applied.”

“The most likely association complex between alcohol and riboflavin is 1 : 1 stoichiometric complex through the 3-N imino and the 2-C carbonyl groups of the isoalloxazine ring and the hydroxyl group of alcohols.”