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Last Updated: 3 years ago

Possible Interaction: Ethanol and Recombinant Interferon Beta

Research Papers that Mention the Interaction

Treatment of hepatocytes with 25-100 mM ethanol for 30 min inhibited IFN-beta- or IFN-gamma-induced STAT1 activation and tyrosine phosphorylation.
The Biochemical journal  •  2000  |  View Paper
The induced IFN is secreted maximally at 6 h, whereas the induction of 2',5'-oligoadenylate synthetase mRNA peaks between 9 … and its activity at 15 h. The appearance of both 2',5'-oligoadenylate synthetase activity and the antiviral state upon ethanol treatment is …-bovine recombinant IFN-beta antibodies.
Together, these results show that: 1) ethanol induces the 2',5'-oligoadenylate synthetase and antiviral activities through IFN-beta production; and 2) the IFN produced does not act directly from inside the cells, but has to be first secreted to bind to its receptor.
The Journal of biological chemistry  •  1992  |  View Paper