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Last Updated: 2 years ago

Possible Interaction: Ethanol and Quinidine





Research Papers that Mention the Interaction

Quinidine , a nonselective blocker of several types of channels (including several K(+) channels) that also antagonizes the Na(+)/K(+) ATPase, reduced the effect of ethanol on GoC firing.
Alcoholism, clinical and experimental research  •  2012  |  View Paper
Interestingly, ethanol excitation of DA VTA neurons was blocked by quinidine (20–80 μM), a drug that blocks many types of delayed rectifier K+ channels, including some insensitive to TEA.
Journal of Pharmacology and Experimental Therapeutics  •  2003  |  View Paper
The combination of quinidine (1-300 microM) and ethanol (120-240 mg/dL) depressed active papillary muscle tension within the clinically useful concentration range.
The combined effects of ethanol and quinidine on cardiac electromechanical coupling are unknown, but both drugs affect cardiac conduction and can cause myocardial depression.
When cells were exposed to ethanol (240 mg/dL) and quinidine (1.5 microM) together, a significant decrease in the quinidine-induced prolongation of the absolute refractory and relative refractory periods was seen.
Journal of electrocardiology  •  1995  |  View Paper
5 Ethanol (3%) had no apparent effect on stretch‐activated K channel kinetics or conductance yet reduced the efficacy of quinidine block.
British journal of pharmacology  •  1995  |  View Paper