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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Quinidine , a nonselective blocker of several types of channels (including several K(+) channels) that also antagonizes the Na(+)/K(+) ATPase, reduced the effect of ethanol on GoC firing.”
Excitation of rat cerebellar Golgi cells by ethanol: further characterization of the mechanism.“Interestingly, ethanol excitation of DA VTA neurons was blocked by quinidine (20–80 μM), a drug that blocks many types of delayed rectifier K+ channels, including some insensitive to TEA.”
“The combination of quinidine (1-300 microM) and ethanol (120-240 mg/dL) depressed active papillary muscle tension within the clinically useful concentration range.”
“The combined effects of ethanol and quinidine on cardiac electromechanical coupling are unknown, but both drugs affect cardiac conduction and can cause myocardial depression.”
“When cells were exposed to ethanol (240 mg/dL) and quinidine (1.5 microM) together, a significant decrease in the quinidine-induced prolongation of the absolute refractory and relative refractory periods was seen.”
“5 Ethanol (3%) had no apparent effect on stretch‐activated K channel kinetics or conductance yet reduced the efficacy of quinidine block.”
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