Possible Interaction: Ethanol and Quercetin

“The ethanol damage of BRL-3A cells could be prevented by 20, 40 and 80 mg/L of quercetin complex , and the protection mechanism of hepatocyte was related to the antioxidation of DNA.”

“ Quercetin attenuated the abnormity induced by ethanol and/or iron.”

“However, the precise mechanism by which quercetin counteracts CYP2E1-mediated ethanol hepatotoxicity through HO-1 system is still remained unclear.”

“Thus, CYP2E1-mediated ethanol hepatotoxicity was alleviated by quercetin through HO-1 induction.”

“ Quercetin prevented the cytotoxicity induced by a variety of hepatotoxicants including clivorine (Cliv), acetaminophen (APAP), ethanol , carbon tetrachloride (CCl4), and toosendanin (TSN) in human normal liver L-02 cells.”

“ Quercetin exerted a dose-dependent protective effect against alcoholic oxidative stress, and increased the EC50 of ethanol by approx.”

“Chemical treatments like QUE and POL reduced behavioral defects induced by ethanol exposure.”

“In conclusion, this study presents new evidence that QUE , POL, FA and their mixtures partially protected epiboly, teratogenic, and behavioral defects induced by ethanol exposure.”

“Chronic-plus-binge ethanol consumption led to lipid droplets accumulation and liver damage as evidenced by histopathological changes, the increased content of triglyceride in serum and liver, and the elevated of serum ALT and AST level, which were greatly attenuated by quercetin.”

“Moreover, quercetin blocked autophagy suppression by chronic-binge ethanol intake as manifested by the morphological improvement of mitochondrial characteristics, the increased number of autolysosome and restoration of autophagy-related protein expression.”

“An ethanol regime to mice for 15 weeks (accounting for 30% of total calories) led to significant mitochondrial damage as evidenced by changes of the mitochondrial ultrastructure, loss of mitochondrial membrane potential and remodeling of membrane lipid composition, which was greatly attenuated by quercetin (100 mg/kg.bw).”

“Histopathological changes caused by ethanol have been improved by quercetin and fish n‐3 fatty acids.”

“It is obvious that quercetin has significant anti-oxidative effects and protects cells both in vivo and in vitro from the adverse effects of alcohol.”

“ Quercetin also mitigates ethanol withdrawal-associated anxiety, and also decreases the incidence of gastric ulcers by decreasing the proliferation of mast cells in gastric tissue (Joshi et al. 2005).”

“Similarly, seizures secondary to ethanol withdrawal are inhibited by quercetin (Tang et al. 2012).”